Template:Typhoid Antibiotics

Oral therapy with Quinolone Susceptibility

• Ciprofloxacin 500-750 mg PO q 12 hrs x 14 days

Parenteral Therapy with Quinolone Susceptibility

• Ciprofloxacin 400 mg IV q 12 hrs x 10 days

Parenteral Therapy with Quinolone Resistance

if nalidixic acid resistant, assume fluoroquinolone resistant

• Ceftriaxone 2g IV q 24 hrs x 14 days

OR

• Cefixime 10-15 mg/kg IV q 12 hrs x 8 days

Oral Therapy with Quinolone Resistance

• Azithromycin 1 g PO daily x 5 days
• Amoxicillin Not 1st line treatment; 50-100mg/kg/day PO divided q6-8h x 14 days; First Dose: 12.5mg-33.3mg/kg PO x 1
• Amoxicillin Not 1st line treatment; 50-100mg/kg/day PO divided q6-8h x 14 days

Pediatric

• Ceftriaxone 50-80mg/kg IV daily x 10-14 days (max 2g)
• Azithromycin 10-20mg/kg PO daily x 5-7 days (max 1g)
• Cefixime 15-20mg/kg/day PO divided BID x 7-14 days (max 400mg/dose)