Template:Septic Arthritis Antibiotics

For adults treatment should be divided into Gonococcal and Non-Gonococcal

Gonococcal

• Ceftriaxone 1g IV once daily
• Cefixime 400 mg PO BID is an option for outpatient therapy after initial 3 days of Ceftriaxone

Non-Gonococcal

• Treatment should cover S. aureus, Streptococcus, Pseudomonas, Enterococcus, B. burgdorferi
• Vancomycin 15-20 mg/kg IV BID PLUS any of the following:
  • Ceftriaxone 2g IV once daily
  • Cefepime 2g IV three times daily
  • Ceftazidime 2g IV three times daily
  • Ciprofloxacin 400mg IV three times daily

Pediatrics

• Ceftriaxone 1g IV once daily

Sickle Cell

Coverage for Salmonella and Staphylococcus spp

• Vancomycin 20mg/kg IV twice daily PLUS
  • Ciprofloxacin 400mg IV three times daily OR
  • Imipenem/Cilastatin 1g IV three times daily