Template:Rocky Mountain Spotted Fever antibiotics: Difference between revisions

(Created page with "*Doxycycline 100 mg BID for 5-7 days<ref>Shandera WX, Roig IL: Viral & Rickettsial Infections, in Papadakis MA, McPhee SJ (eds): Current Medical Diagnosis and Treatment, e...")
 
(Add pediatric dosing - doxycycline first line for all ages per CDC)
 
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*[[Doxycycline]] 100 mg BID for 5-7 days<ref>Shandera WX, Roig IL: Viral & Rickettsial Infections, in Papadakis MA, McPhee SJ (eds): Current Medical Diagnosis and Treatment, ed 52. USA, McGraw-Hill, 2013, (Ch) 32: p 1412-1413.</ref>
*{{AntibioticDose|disease=Rocky mountain spotted fever|drug=Doxycycline|dose=100mg PO BID x 5-7 days|context=First line|population=Adult}}<ref>Shandera WX, Roig IL: Viral & Rickettsial Infections, in Papadakis MA, McPhee SJ (eds): Current Medical Diagnosis and Treatment, ed 52. USA, McGraw-Hill, 2013, (Ch) 32: p 1412-1413.</ref>
**Indicated also in children at 2.2mg/kg BID
**Indicated also in children at 2.2mg/kg BID
*[[Chloramphenicol]] (CAM) 50-100 mg/kg/day div Q6hr (Max dose = 4g/day)
*{{AntibioticDose|disease=Rocky mountain spotted fever|drug=Chloramphenicol|dose=50-100mg/kg/day div q6hrs (max 4g/day)|context=Preferred in pregnancy|population=Adult}}
**Preferred agent in pregnancy. May cause [[aplastic anemia]] and [[Grey baby syndrome]], more common in near term or 3rd trimester<ref name="http://www.cdc.gov/rmsf/">http://www.cdc.gov/rmsf/</ref>
**Preferred agent in pregnancy. May cause [[aplastic anemia]] and [[Grey baby syndrome]], more common in near term or 3rd trimester<ref name="http://www.cdc.gov/rmsf/">http://www.cdc.gov/rmsf/</ref>
**Consideration should be made for doxycycline over CAM in the 3rd trimester
**Consideration should be made for doxycycline over CAM in the 3rd trimester
====Pediatric====
''Doxycycline is the first-line treatment for RMSF in children of ALL ages per CDC and AAP''
*{{AntibioticDose|disease=Rocky mountain spotted fever|drug=Doxycycline|dose=2.2mg/kg PO/IV BID (max 100mg/dose) x 5-7 days or until afebrile x 3 days|context=Pediatric First Line|population=Pediatric}}
*{{AntibioticDose|disease=Rocky mountain spotted fever|drug=Chloramphenicol|dose=50-100mg/kg/day IV divided q6hrs (max 4g/day)|context=Pediatric Doxycycline Allergy|population=Pediatric}} if doxycycline allergy

Latest revision as of 13:11, 20 March 2026

  • Doxycycline 100mg PO BID x 5-7 days[1]
    • Indicated also in children at 2.2mg/kg BID
  • Chloramphenicol 50-100mg/kg/day div q6hrs (max 4g/day)
    • Preferred agent in pregnancy. May cause aplastic anemia and Grey baby syndrome, more common in near term or 3rd trimester[2]
    • Consideration should be made for doxycycline over CAM in the 3rd trimester

Pediatric

Doxycycline is the first-line treatment for RMSF in children of ALL ages per CDC and AAP

  • Doxycycline 2.2mg/kg PO/IV BID (max 100mg/dose) x 5-7 days or until afebrile x 3 days
  • Chloramphenicol 50-100mg/kg/day IV divided q6hrs (max 4g/day) if doxycycline allergy
  1. ↑ Shandera WX, Roig IL: Viral & Rickettsial Infections, in Papadakis MA, McPhee SJ (eds): Current Medical Diagnosis and Treatment, ed 52. USA, McGraw-Hill, 2013, (Ch) 32: p 1412-1413.
  2. ↑ http://www.cdc.gov/rmsf/
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