Template:Mastoiditis Antibiotics: Difference between revisions
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''Coverage against [[S. pneumoniae]], S. pyogenes, [[S. aureus]], [[H. influenzae]]'' | ''Coverage against [[S. pneumoniae]], S. pyogenes, [[S. aureus]], [[H. influenzae]]'' | ||
*{{AntibioticDose|drug=Clindamycin|dose=600mg IV q8 hours|context=Empiric}} '''OR''' (if [[MRSA]] concern use [[Vancomycin]] regimen) | *{{AntibioticDose|disease=Mastoiditis|drug=Clindamycin|dose=600mg IV q8 hours|context=Empiric}} '''OR''' (if [[MRSA]] concern use [[Vancomycin]] regimen) | ||
*{{AntibioticDose|drug=Vancomycin|dose=15-20mg/kg IV q12 hours|context=Empiric}} '''PLUS''' | *{{AntibioticDose|disease=Mastoiditis|drug=Vancomycin|dose=15-20mg/kg IV q12 hours|context=Empiric}} '''PLUS''' | ||
**{{AntibioticDose|drug=Ceftriaxone|dose=1g (50mg/kg) IV once daily|context=Empiric}} '''OR''' | **{{AntibioticDose|disease=Mastoiditis|drug=Ceftriaxone|dose=1g (50mg/kg) IV once daily|context=Empiric}} '''OR''' | ||
**{{AntibioticDose|drug=Ampicillin/Sulbactam|dose=3g (50mg/kg) IV q6 hours|context=Empiric}} | **{{AntibioticDose|disease=Mastoiditis|drug=Ampicillin/Sulbactam|dose=3g (50mg/kg) IV q6 hours|context=Empiric}} | ||
*If chronic or severe, need pseudomonas coverage | *If chronic or severe, need pseudomonas coverage | ||
** [[Vancomycin]] + {{AntibioticDose|drug=Piperacillin/Tazobactam|dose=100mg/kg/dose piperacillin IV q6h (max 4g piperacillin/dose)|context=Chronic/Severe}} | ** [[Vancomycin]] + {{AntibioticDose|disease=Mastoiditis|drug=Piperacillin/Tazobactam|dose=100mg/kg/dose piperacillin IV q6h (max 4g piperacillin/dose)|context=Chronic/Severe}} | ||
====Pediatric==== | |||
*{{AntibioticDose|disease=Mastoiditis|drug=Ceftriaxone|dose=50mg/kg IV daily (max 2g)|context=Pediatric Empiric|population=Pediatric}} '''OR''' | |||
*{{AntibioticDose|disease=Mastoiditis|drug=Ampicillin/Sulbactam|dose=50mg/kg IV q6hrs (max 3g/dose)|context=Pediatric Empiric|population=Pediatric}} | |||
*If MRSA concern: add {{AntibioticDose|disease=Mastoiditis|drug=Vancomycin|dose=15mg/kg IV q6hrs|context=Pediatric MRSA|population=Pediatric}} | |||
*If chronic/severe: {{AntibioticDose|disease=Mastoiditis|drug=Piperacillin/Tazobactam|dose=100mg/kg IV q6hrs (max 4.5g/dose)|context=Pediatric Chronic/Severe|population=Pediatric}} + Vancomycin | |||
*{{AntibioticDose|disease=Mastoiditis|drug=Clindamycin|dose=10-13mg/kg IV q8hrs (max 900mg/dose)|context=Pediatric|population=Pediatric}} as alternative | |||
Latest revision as of 12:58, 20 March 2026
Coverage against S. pneumoniae, S. pyogenes, S. aureus, H. influenzae
- Clindamycin 600mg IV q8 hours OR (if MRSA concern use Vancomycin regimen)
- Vancomycin 15-20mg/kg IV q12 hours PLUS
- Ceftriaxone 1g (50mg/kg) IV once daily OR
- Ampicillin/Sulbactam 3g (50mg/kg) IV q6 hours
- If chronic or severe, need pseudomonas coverage
- Vancomycin + Piperacillin/Tazobactam 100mg/kg/dose piperacillin IV q6h (max 4g piperacillin/dose)
Pediatric
- Ceftriaxone 50mg/kg IV daily (max 2g) OR
- Ampicillin/Sulbactam 50mg/kg IV q6hrs (max 3g/dose)
- If MRSA concern: add Vancomycin 15mg/kg IV q6hrs
- If chronic/severe: Piperacillin/Tazobactam 100mg/kg IV q6hrs (max 4.5g/dose) + Vancomycin
- Clindamycin 10-13mg/kg IV q8hrs (max 900mg/dose) as alternative