Template:Osteomyelitis Antibiotics: Difference between revisions
(Add AntibioticDose entries: Dicloxacillin) |
(Fix incomplete doses: add route/frequency for Vancomycin, Pip/Tazo, Imipenem) |
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| Elderly, hematogenous spread | | Elderly, hematogenous spread | ||
| [[MRSA]], [[MSSA]], [[gram neg]] | | [[MRSA]], [[MSSA]], [[gram neg]] | ||
| {{AntibioticDose|disease=Osteomyelitis|drug=Vancomycin|dose= | | {{AntibioticDose|disease=Osteomyelitis|drug=Vancomycin|dose=1g IV q12h|context=Elderly/Hematogenous}} + ({{AntibioticDose|disease=Osteomyelitis|drug=Piperacillin/Tazobactam|dose=3.375g IV q6h|context=Elderly/Hematogenous}} OR {{AntibioticDose|disease=Osteomyelitis|drug=Imipenem|dose=500mg IV q6h|context=Elderly/Hematogenous}}) | ||
|- | |- | ||
| [[Sickle Cell Disease]] | | [[Sickle Cell Disease]] | ||
| Line 18: | Line 18: | ||
| [[DM]] or vascular insufficiency | | [[DM]] or vascular insufficiency | ||
| Polymicrobial: [[Staph]], [[strep]], coliforms, [[anaerobes]] | | Polymicrobial: [[Staph]], [[strep]], coliforms, [[anaerobes]] | ||
| {{AntibioticDose|disease=Osteomyelitis|drug=Vancomycin|dose= | | {{AntibioticDose|disease=Osteomyelitis|drug=Vancomycin|dose=1g IV q12h|context=DM/Vascular insufficiency}} + ({{AntibioticDose|disease=Osteomyelitis|drug=Piperacillin/Tazobactam|dose=3.375g IV q6h|context=DM/Vascular insufficiency}} OR {{AntibioticDose|disease=Osteomyelitis|drug=Imipenem|dose=500mg IV q6h|context=DM/Vascular insufficiency}}) | ||
|- | |- | ||
| [[IVDU|IV drug]] user | | [[IVDU|IV drug]] user | ||
| [[MRSA]], [[MSSA]], [[pseudomonas]] | | [[MRSA]], [[MSSA]], [[pseudomonas]] | ||
| {{AntibioticDose|disease=Osteomyelitis|drug=Vancomycin|dose= | | {{AntibioticDose|disease=Osteomyelitis|drug=Vancomycin|dose=1g IV q12h|context=IVDU}} | ||
|- | |- | ||
| Newborn | | Newborn | ||
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| Postoperative (ortho) | | Postoperative (ortho) | ||
| [[MRSA]], [[MSSA]] | | [[MRSA]], [[MSSA]] | ||
| {{AntibioticDose|disease=Osteomyelitis|drug=Vancomycin|dose= | | {{AntibioticDose|disease=Osteomyelitis|drug=Vancomycin|dose=1g IV q12h|context=Postoperative}} | ||
|- | |- | ||
| [[Human bite]] | | [[Human bite]] | ||
| [[Strep]], [[anaerobes]], HACEK organism | | [[Strep]], [[anaerobes]], HACEK organism | ||
| {{AntibioticDose|disease=Osteomyelitis|drug=Piperacillin/Tazobactam|dose=3.375gm|context=Human bite}} OR {{AntibioticDose|disease=Osteomyelitis|drug=Imipenem|dose=500mg|context=Human bite}} | | {{AntibioticDose|disease=Osteomyelitis|drug=Piperacillin/Tazobactam|dose=3.375gm|context=Human bite}} OR {{AntibioticDose|disease=Osteomyelitis|drug=Imipenem|dose=500mg IV q6h|context=Human bite}} | ||
|- | |- | ||
| [[Animal bites]] | | [[Animal bites]] | ||
| [[Pasteurella]], [[Eikenella]], HACEK organism | | [[Pasteurella]], [[Eikenella]], HACEK organism | ||
| {{AntibioticDose|disease=Osteomyelitis|drug=Piperacillin/Tazobactam|dose=3.375gm|context=Animal bites}} OR {{AntibioticDose|disease=Osteomyelitis|drug=Imipenem|dose=500mg|context=Animal bites}} | | {{AntibioticDose|disease=Osteomyelitis|drug=Piperacillin/Tazobactam|dose=3.375gm|context=Animal bites}} OR {{AntibioticDose|disease=Osteomyelitis|drug=Imipenem|dose=500mg IV q6h|context=Animal bites}} | ||
|- | |- | ||
| Foot puncture wound | | Foot puncture wound | ||
Latest revision as of 11:30, 20 March 2026
| Risk Factor | Likely Organism | Initial Empiric Antibiotic Therapy' |
| Elderly, hematogenous spread | MRSA, MSSA, gram neg | Vancomycin 1g IV q12h + (Piperacillin/Tazobactam 3.375g IV q6h OR Imipenem 500mg IV q6h) |
| Sickle Cell Disease | Salmonella, gram-negative bacteria | Ceftriaxone 50mg/kg IV once daily OR Cefotaxime 50mg/kg IV three times daily, PLUS
|
| DM or vascular insufficiency | Polymicrobial: Staph, strep, coliforms, anaerobes | Vancomycin 1g IV q12h + (Piperacillin/Tazobactam 3.375g IV q6h OR Imipenem 500mg IV q6h) |
| IV drug user | MRSA, MSSA, pseudomonas | Vancomycin 1g IV q12h |
| Newborn | MRSA, MSSA, GBS, Gram Negative | Vancomycin 15mg/kg load, then reduce dose, AND Ceftazidime 30mg/kg IV q12 h |
| Children | MRSA, MSSA | Vancomycin 10mg/kg q6 h AND Ceftazidime 50mg/kg q8hr |
| Postoperative (ortho) | MRSA, MSSA | Vancomycin 1g IV q12h |
| Human bite | Strep, anaerobes, HACEK organism | Piperacillin/Tazobactam 3.375gm OR Imipenem 500mg IV q6h |
| Animal bites | Pasteurella, Eikenella, HACEK organism | Piperacillin/Tazobactam 3.375gm OR Imipenem 500mg IV q6h |
| Foot puncture wound | Pseudomonas | Anti-pseudomonal, staph coverage |
- Dicloxacillin <40kg: 50-100mg/kg/day PO divided q6h; >40kg: 250-500mg PO q6h