Template:Antibiotics Open Fracture - Revision history

Danbot: Add pediatric dosing for open fracture prophylaxis

2026-03-20T13:16:43Z

Add pediatric dosing for open fracture prophylaxis

← Older revision		Revision as of 13:16, 20 March 2026
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	*Fresh water wounds: [[fluoroquinolones\|fluoroquinolones]] OR 3rd/4th generation [[cephalosporin\|cephalosporin]]		*Fresh water wounds: [[fluoroquinolones\|fluoroquinolones]] OR 3rd/4th generation [[cephalosporin\|cephalosporin]]
	*Saltwater wounds ([[vibrio\|vibrio]]): [[doxycycline\|doxycycline]] + [[ceftazidime\|ceftazidime]] OR [[fluoroquinolone\|fluoroquinolone]]		*Saltwater wounds ([[vibrio\|vibrio]]): [[doxycycline\|doxycycline]] + [[ceftazidime\|ceftazidime]] OR [[fluoroquinolone\|fluoroquinolone]]

			====Pediatric====
			=====Grade I & II=====
			*{{AntibioticDose\|disease=Open fracture\|drug=Cefazolin\|dose=25mg/kg IV (max 2g) immediately then q8hrs x 3 doses\|context=Pediatric Grade I & II\|population=Pediatric}}
			*Cephalosporin allergy: {{AntibioticDose\|disease=Open fracture\|drug=Clindamycin\|dose=10mg/kg IV (max 900mg) immediately then q8hrs x 3 doses\|context=Pediatric Grade I & II, allergy\|population=Pediatric}}
			=====Grade III=====
			*{{AntibioticDose\|disease=Open fracture\|drug=Ceftriaxone\|dose=50mg/kg IV (max 2g) x 1\|context=Pediatric Grade III\|population=Pediatric}} + {{AntibioticDose\|disease=Open fracture\|drug=Vancomycin\|dose=15mg/kg IV (max 1g) then q12hrs x 2 doses\|context=Pediatric Grade III\|population=Pediatric}}
			*Cephalosporin allergy: {{AntibioticDose\|disease=Open fracture\|drug=Aztreonam\|dose=30mg/kg IV (max 2g) then q8hrs x 3\|context=Pediatric Grade III, allergy\|population=Pediatric}} + Vancomycin

Danbot: Strip translate tags to enable SMW subobject creation

2026-03-20T02:53:43Z

Strip translate tags to enable SMW subobject creation

← Older revision		Revision as of 02:53, 20 March 2026
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	~~<noinclude><languages/></noinclude>~~		===Prophylactic Antibiotics for [[Open fractures\|Open fractures]]===
	~~<translate>~~
	===Prophylactic Antibiotics for [[~~Special:MyLanguage/~~Open fractures\|Open fractures]]===

	~~<!--T:2-->~~
	''Initiate as soon as possible; increased infection rate when delayed<ref>Gosselin RA, et al. Antibiotics for preventing infection in open limb fractures. Cochrane Database Syst Rev. 2004; (1):CD003764.</ref>''		''Initiate as soon as possible; increased infection rate when delayed<ref>Gosselin RA, et al. Antibiotics for preventing infection in open limb fractures. Cochrane Database Syst Rev. 2004; (1):CD003764.</ref>''

	====[[~~Special:MyLanguage/~~Open_fracture\|Grade I & II Fractures]] Options====		====[[Open_fracture\|Grade I & II Fractures]] Options====

	~~<!--T:4-->~~
	*{{AntibioticDose\|disease=Open fracture\|drug=Cefazolin\|dose=2 g IV (immediately and q8 hours x 3 total doses)\|context=Grade I & II Fractures}} (Ancef)<ref name=Garner2020>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>		*{{AntibioticDose\|disease=Open fracture\|drug=Cefazolin\|dose=2 g IV (immediately and q8 hours x 3 total doses)\|context=Grade I & II Fractures}} (Ancef)<ref name=Garner2020>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>
	*Cephalosporin allergy: {{AntibioticDose\|disease=Open fracture\|drug=Clindamycin\|dose=900 mg IV (immediately and q8 hours x 3 total doses)\|context=Grade I & II, Cephalosporin allergy}}<ref name=Garner2020/>		*Cephalosporin allergy: {{AntibioticDose\|disease=Open fracture\|drug=Clindamycin\|dose=900 mg IV (immediately and q8 hours x 3 total doses)\|context=Grade I & II, Cephalosporin allergy}}<ref name=Garner2020/>

	====[[~~Special:MyLanguage/~~Open_fracture#Grade_III\|Grade III Fracture]] Options====		====[[Open_fracture#Grade_III\|Grade III Fracture]] Options====

	~~<!--T:6-->~~
	*{{AntibioticDose\|disease=Open fracture\|drug=Ceftriaxone\|dose=2 g IV (immediately x 1 total dose)\|context=Grade III Fractures}} PLUS {{AntibioticDose\|disease=Open fracture\|drug=Vancomycin\|dose=1 g IV (immediately and q12 hours x 2 total doses)\|context=Grade III Fractures}}<ref name=Garner2020/>		*{{AntibioticDose\|disease=Open fracture\|drug=Ceftriaxone\|dose=2 g IV (immediately x 1 total dose)\|context=Grade III Fractures}} PLUS {{AntibioticDose\|disease=Open fracture\|drug=Vancomycin\|dose=1 g IV (immediately and q12 hours x 2 total doses)\|context=Grade III Fractures}}<ref name=Garner2020/>
	*Cephalosporin allergy: {{AntibioticDose\|disease=Open fracture\|drug=Aztreonam\|dose=2 g IV (immediately and q8 hours x 3)\|context=Grade III, Cephalosporin allergy}} PLUS [[Vancomycin]] 1 g IV (immediately and q12 hours x 2 total doses)<ref name=Garner2020/>		*Cephalosporin allergy: {{AntibioticDose\|disease=Open fracture\|drug=Aztreonam\|dose=2 g IV (immediately and q8 hours x 3)\|context=Grade III, Cephalosporin allergy}} PLUS [[Vancomycin]] 1 g IV (immediately and q12 hours x 2 total doses)<ref name=Garner2020/>
Line 20:		Line 15:
	====Special Considerations====		====Special Considerations====

	~~<!--T:8-->~~		*Concern for [[clostridium\|clostridium]] (soil contamination, farm injuries, possible bowel contamination): additionally add [[penicillin\|penicillin]]<ref>HoffWS, Bonadies JA, Cachecho R, Dorlac WC: East practice management guidelines work group: Update to practice management guidelines for prophylactic antibiotic use in open fractures. J Trauma 2011;70:751-754.</ref><ref name=Garner2020/>
	*Concern for [[~~Special:MyLanguage/~~clostridium\|clostridium]] (soil contamination, farm injuries, possible bowel contamination): additionally add [[~~Special:MyLanguage/~~penicillin\|penicillin]]<ref>HoffWS, Bonadies JA, Cachecho R, Dorlac WC: East practice management guidelines work group: Update to practice management guidelines for prophylactic antibiotic use in open fractures. J Trauma 2011;70:751-754.</ref><ref name=Garner2020/>		*Fresh water wounds: [[fluoroquinolones\|fluoroquinolones]] OR 3rd/4th generation [[cephalosporin\|cephalosporin]]
	*Fresh water wounds: [[~~Special:MyLanguage/~~fluoroquinolones\|fluoroquinolones]] OR 3rd/4th generation [[~~Special:MyLanguage/~~cephalosporin\|cephalosporin]]		*Saltwater wounds ([[vibrio\|vibrio]]): [[doxycycline\|doxycycline]] + [[ceftazidime\|ceftazidime]] OR [[fluoroquinolone\|fluoroquinolone]]
	*Saltwater wounds ([[~~Special:MyLanguage/~~vibrio\|vibrio]]): [[~~Special:MyLanguage/~~doxycycline\|doxycycline]] + [[~~Special:MyLanguage/~~ceftazidime\|ceftazidime]] OR [[~~Special:MyLanguage/~~fluoroquinolone\|fluoroquinolone]]
	~~</translate>~~

Danbot: Add disease=Open fracture parameter to AntibioticDose calls - fixes aggregation page display issue

2026-03-19T23:11:47Z

Add disease=Open fracture parameter to AntibioticDose calls - fixes aggregation page display issue

← Older revision		Revision as of 23:11, 19 March 2026
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	<!--T:4-->		<!--T:4-->
	*{{AntibioticDose\|drug=Cefazolin\|dose=2 g IV (immediately and q8 hours x 3 total doses)\|context=Grade I & II Fractures}} (Ancef)<ref name=Garner2020>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>		*{{AntibioticDose\|disease=Open fracture\|drug=Cefazolin\|dose=2 g IV (immediately and q8 hours x 3 total doses)\|context=Grade I & II Fractures}} (Ancef)<ref name=Garner2020>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>
	*Cephalosporin allergy: {{AntibioticDose\|drug=Clindamycin\|dose=900 mg IV (immediately and q8 hours x 3 total doses)\|context=Grade I & II, Cephalosporin allergy}}<ref name=Garner2020/>		*Cephalosporin allergy: {{AntibioticDose\|disease=Open fracture\|drug=Clindamycin\|dose=900 mg IV (immediately and q8 hours x 3 total doses)\|context=Grade I & II, Cephalosporin allergy}}<ref name=Garner2020/>

	====[[Special:MyLanguage/Open_fracture#Grade_III\|Grade III Fracture]] Options====		====[[Special:MyLanguage/Open_fracture#Grade_III\|Grade III Fracture]] Options====

	<!--T:6-->		<!--T:6-->
	*{{AntibioticDose\|drug=Ceftriaxone\|dose=2 g IV (immediately x 1 total dose)\|context=Grade III Fractures}} PLUS {{AntibioticDose\|drug=Vancomycin\|dose=1 g IV (immediately and q12 hours x 2 total doses)\|context=Grade III Fractures}}<ref name=Garner2020/>		*{{AntibioticDose\|disease=Open fracture\|drug=Ceftriaxone\|dose=2 g IV (immediately x 1 total dose)\|context=Grade III Fractures}} PLUS {{AntibioticDose\|disease=Open fracture\|drug=Vancomycin\|dose=1 g IV (immediately and q12 hours x 2 total doses)\|context=Grade III Fractures}}<ref name=Garner2020/>
	*Cephalosporin allergy: {{AntibioticDose\|drug=Aztreonam\|dose=2 g IV (immediately and q8 hours x 3)\|context=Grade III, Cephalosporin allergy}} PLUS [[Vancomycin]] 1 g IV (immediately and q12 hours x 2 total doses)<ref name=Garner2020/>		*Cephalosporin allergy: {{AntibioticDose\|disease=Open fracture\|drug=Aztreonam\|dose=2 g IV (immediately and q8 hours x 3)\|context=Grade III, Cephalosporin allergy}} PLUS [[Vancomycin]] 1 g IV (immediately and q12 hours x 2 total doses)<ref name=Garner2020/>

	====Special Considerations====		====Special Considerations====

Danbot: Convert to {{AntibioticDose}} for SMW antibiotic-disease linking (Cefazolin, Clindamycin, Ceftriaxone, Vancomycin, Aztreonam)

2026-03-19T20:38:34Z

Convert to {{AntibioticDose}} for SMW antibiotic-disease linking (Cefazolin, Clindamycin, Ceftriaxone, Vancomycin, Aztreonam)

← Older revision		Revision as of 20:38, 19 March 2026
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	<noinclude><languages/></noinclude>		<noinclude><languages/></noinclude>
	<translate>		<translate>
			===Prophylactic Antibiotics for [[Special:MyLanguage/Open fractures\|Open fractures]]===
	===Prophylactic Antibiotics for [[Special:MyLanguage/Open fractures\|Open fractures]]=== ~~<!--T:1-->~~

	<!--T:2-->		<!--T:2-->
	''Initiate as soon as possible; increased infection rate when delayed<ref>Gosselin RA, et al. Antibiotics for preventing infection in open limb fractures. Cochrane Database Syst Rev. 2004; (1):CD003764.</ref>''		''Initiate as soon as possible; increased infection rate when delayed<ref>Gosselin RA, et al. Antibiotics for preventing infection in open limb fractures. Cochrane Database Syst Rev. 2004; (1):CD003764.</ref>''

			====[[Special:MyLanguage/Open_fracture\|Grade I & II Fractures]] Options====
	====[[Special:MyLanguage/Open_fracture\|Grade I & II Fractures]] Options==== ~~<!--T:3-->~~

	<!--T:4-->		<!--T:4-->
	*~~[[Special:MyLanguage/~~Cefazolin\|~~Cefazolin]] (Ancef)~~ 2 g IV (immediately and q8 hours x 3 total doses)<ref name=Garner2020>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>		*{{AntibioticDose\|drug=Cefazolin\|dose=2 g IV (immediately and q8 hours x 3 total doses)\|context=Grade I & II Fractures}} (Ancef)<ref name=Garner2020>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>
	*Cephalosporin allergy: ~~[[Special:MyLanguage/clindamycin~~\|~~clindamycin]]~~ 900 mg IV (immediately and q8 hours x 3 total doses)<ref name=Garner2020~~>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315<~~/~~ref~~>		*Cephalosporin allergy: {{AntibioticDose\|drug=Clindamycin\|dose=900 mg IV (immediately and q8 hours x 3 total doses)\|context=Grade I & II, Cephalosporin allergy}}<ref name=Garner2020/>


	====[[Special:MyLanguage/Open_fracture#Grade_III\|Grade III Fracture]] Options==== ~~<!--T:5-->~~		====[[Special:MyLanguage/Open_fracture#Grade_III\|Grade III Fracture]] Options====

	<!--T:6-->		<!--T:6-->
	*~~[[Special:MyLanguage/~~Ceftriaxone\|~~Ceftriaxone]]~~ 2 g IV (immediately x 1 total dose) PLUS ~~[[Special:MyLanguage/vancomycin~~\|~~vancomycin]]~~ 1 g IV (immediately and q12 hours x 2 total doses)<ref name=Garner2020~~>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315<~~/~~ref~~>		*{{AntibioticDose\|drug=Ceftriaxone\|dose=2 g IV (immediately x 1 total dose)\|context=Grade III Fractures}} PLUS {{AntibioticDose\|drug=Vancomycin\|dose=1 g IV (immediately and q12 hours x 2 total doses)\|context=Grade III Fractures}}<ref name=Garner2020/>
	*Cephalosporin allergy: ~~[[Special:MyLanguage/aztreonam~~\|~~aztreonam]]~~ 2 g IV (immediately and q8 hours x 3) PLUS [[~~Special:MyLanguage/vancomycin\|vancomycin~~]] 1 g IV (immediately and q12 hours x 2 total doses)<ref name=Garner2020~~>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315<~~/~~ref~~>		*Cephalosporin allergy: {{AntibioticDose\|drug=Aztreonam\|dose=2 g IV (immediately and q8 hours x 3)\|context=Grade III, Cephalosporin allergy}} PLUS [[Vancomycin]] 1 g IV (immediately and q12 hours x 2 total doses)<ref name=Garner2020/>


	====Special Considerations==== ~~<!--T:7-->~~		====Special Considerations====

	<!--T:8-->		<!--T:8-->
	*Concern for [[Special:MyLanguage/clostridium\|clostridium]] (soil contamination, farm injuries, possible bowel contamination): additionally add [[Special:MyLanguage/penicillin\|penicillin]]<ref>HoffWS, Bonadies JA, Cachecho R, Dorlac WC: East practice management guidelines work group: Update to practice management guidelines for prophylactic antibiotic use in open fractures. J Trauma 2011;70:751-754.</ref><ref name=Garner2020~~>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315<~~/~~ref~~>		*Concern for [[Special:MyLanguage/clostridium\|clostridium]] (soil contamination, farm injuries, possible bowel contamination): additionally add [[Special:MyLanguage/penicillin\|penicillin]]<ref>HoffWS, Bonadies JA, Cachecho R, Dorlac WC: East practice management guidelines work group: Update to practice management guidelines for prophylactic antibiotic use in open fractures. J Trauma 2011;70:751-754.</ref><ref name=Garner2020/>
	*Fresh water wounds: [[Special:MyLanguage/fluoroquinolones\|fluoroquinolones]] OR 3rd/4th generation [[Special:MyLanguage/cephalosporin\|cephalosporin]]		*Fresh water wounds: [[Special:MyLanguage/fluoroquinolones\|fluoroquinolones]] OR 3rd/4th generation [[Special:MyLanguage/cephalosporin\|cephalosporin]]
	*Saltwater wounds ([[Special:MyLanguage/vibrio\|vibrio]]): [[Special:MyLanguage/doxycycline\|doxycycline]] + [[Special:MyLanguage/ceftazidime\|ceftazidime]] OR [[Special:MyLanguage/fluoroquinolone\|fluoroquinolone]]		*Saltwater wounds ([[Special:MyLanguage/vibrio\|vibrio]]): [[Special:MyLanguage/doxycycline\|doxycycline]] + [[Special:MyLanguage/ceftazidime\|ceftazidime]] OR [[Special:MyLanguage/fluoroquinolone\|fluoroquinolone]]
	</translate>		</translate>

Ostermayer: Marked this version for translation

2026-01-23T08:32:52Z

Marked this version for translation

Ostermayer at 08:32, 23 January 2026

2026-01-23T08:32:40Z

← Older revision		Revision as of 08:32, 23 January 2026
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	<languages/>		<noinclude><languages/></noinclude>
	<translate>		<translate>

Ostermayer: Prepared the page for translation

2026-01-23T08:32:20Z

Prepared the page for translation

← Older revision		Revision as of 08:32, 23 January 2026
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	===Prophylactic Antibiotics for [[Open fractures]]===		<languages/>
			<translate>

			===Prophylactic Antibiotics for [[Special:MyLanguage/Open fractures\|Open fractures]]===

	''Initiate as soon as possible; increased infection rate when delayed<ref>Gosselin RA, et al. Antibiotics for preventing infection in open limb fractures. Cochrane Database Syst Rev. 2004; (1):CD003764.</ref>''		''Initiate as soon as possible; increased infection rate when delayed<ref>Gosselin RA, et al. Antibiotics for preventing infection in open limb fractures. Cochrane Database Syst Rev. 2004; (1):CD003764.</ref>''

	~~====[[Open_fracture\|Grade I & II Fractures]] Options====~~
	*[[Cefazolin]] (Ancef) 2 g IV (immediately and q8 hours x 3 total doses)<ref name=Garner2020>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>
	*Cephalosporin allergy: [[clindamycin]] 900 mg IV (immediately and q8 hours x 3 total doses)<ref name=Garner2020>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>

	====[[Open_fracture#Grade_III\|Grade III Fracture]] Options====		====[[Special:MyLanguage/Open_fracture\|Grade I & II Fractures]] Options====
	*[[Ceftriaxone]] 2 g IV (immediately x 1 total dose) PLUS [[vancomycin]] 1 g IV (immediately and q12 hours x 2 total doses)<ref name=Garner2020>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>
	*Cephalosporin allergy: [[aztreonam]] 2 g IV (immediately and q8 hours x 3) PLUS [[vancomycin]] 1 g IV (immediately and q12 hours x 2 total doses)<ref name=Garner2020>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>		*[[Special:MyLanguage/Cefazolin\|Cefazolin]] (Ancef) 2 g IV (immediately and q8 hours x 3 total doses)<ref name=Garner2020>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>
			*Cephalosporin allergy: [[Special:MyLanguage/clindamycin\|clindamycin]] 900 mg IV (immediately and q8 hours x 3 total doses)<ref name=Garner2020>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>


			====[[Special:MyLanguage/Open_fracture#Grade_III\|Grade III Fracture]] Options====

			*[[Special:MyLanguage/Ceftriaxone\|Ceftriaxone]] 2 g IV (immediately x 1 total dose) PLUS [[Special:MyLanguage/vancomycin\|vancomycin]] 1 g IV (immediately and q12 hours x 2 total doses)<ref name=Garner2020>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>
			*Cephalosporin allergy: [[Special:MyLanguage/aztreonam\|aztreonam]] 2 g IV (immediately and q8 hours x 3) PLUS [[Special:MyLanguage/vancomycin\|vancomycin]] 1 g IV (immediately and q12 hours x 2 total doses)<ref name=Garner2020>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>


	====Special Considerations====		====Special Considerations====
	*Concern for [[clostridium]] (soil contamination, farm injuries, possible bowel contamination): additionally add [[penicillin]]<ref>HoffWS, Bonadies JA, Cachecho R, Dorlac WC: East practice management guidelines work group: Update to practice management guidelines for prophylactic antibiotic use in open fractures. J Trauma 2011;70:751-754.</ref><ref name=Garner2020>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>
	*Fresh water wounds: [[fluoroquinolones]] OR 3rd/4th generation [[cephalosporin]]		*Concern for [[Special:MyLanguage/clostridium\|clostridium]] (soil contamination, farm injuries, possible bowel contamination): additionally add [[Special:MyLanguage/penicillin\|penicillin]]<ref>HoffWS, Bonadies JA, Cachecho R, Dorlac WC: East practice management guidelines work group: Update to practice management guidelines for prophylactic antibiotic use in open fractures. J Trauma 2011;70:751-754.</ref><ref name=Garner2020>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>
	*Saltwater wounds ([[vibrio]]): [[doxycycline]] + [[ceftazidime]] OR [[fluoroquinolone]]		*Fresh water wounds: [[Special:MyLanguage/fluoroquinolones\|fluoroquinolones]] OR 3rd/4th generation [[Special:MyLanguage/cephalosporin\|cephalosporin]]
			*Saltwater wounds ([[Special:MyLanguage/vibrio\|vibrio]]): [[Special:MyLanguage/doxycycline\|doxycycline]] + [[Special:MyLanguage/ceftazidime\|ceftazidime]] OR [[Special:MyLanguage/fluoroquinolone\|fluoroquinolone]]
			</translate>

Rossdonaldson1: /* Prophylactic Antibiotics for Open fractures */

2022-05-14T09:58:17Z

Prophylactic Antibiotics for Open fractures

← Older revision		Revision as of 09:58, 14 May 2022
Line 3:		Line 3:

	====[[Open_fracture\|Grade I & II Fractures]] Options====		====[[Open_fracture\|Grade I & II Fractures]] Options====
	*[[Cefazolin]] (Ancef) 2 g IV (immediately and q8 hours x 3 total doses)<ref name=Garner2020/>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>		*[[Cefazolin]] (Ancef) 2 g IV (immediately and q8 hours x 3 total doses)<ref name=Garner2020>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>
	*Cephalosporin allergy: [[clindamycin]] 900 mg IV (immediately and q8 hours x 3 total doses)<ref name=Garner2020/>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>		*Cephalosporin allergy: [[clindamycin]] 900 mg IV (immediately and q8 hours x 3 total doses)<ref name=Garner2020>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>

	====[[Open_fracture#Grade_III\|Grade III Fracture]] Options====		====[[Open_fracture#Grade_III\|Grade III Fracture]] Options====
	*[[Ceftriaxone]] 2 g IV (immediately x 1 total dose) PLUS [[vancomycin]] 1 g IV (immediately and q12 hours x 2 total doses)<ref name=Garner2020/>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>		*[[Ceftriaxone]] 2 g IV (immediately x 1 total dose) PLUS [[vancomycin]] 1 g IV (immediately and q12 hours x 2 total doses)<ref name=Garner2020>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>
	*Cephalosporin allergy: [[aztreonam]] 2 g IV (immediately and q8 hours x 3) PLUS [[vancomycin]] 1 g IV (immediately and q12 hours x 2 total doses)<ref name=Garner2020/>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>		*Cephalosporin allergy: [[aztreonam]] 2 g IV (immediately and q8 hours x 3) PLUS [[vancomycin]] 1 g IV (immediately and q12 hours x 2 total doses)<ref name=Garner2020>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>

	====Special Considerations====		====Special Considerations====
	*Concern for [[clostridium]] (soil contamination, farm injuries, possible bowel contamination): additionally add [[penicillin]]<ref>HoffWS, Bonadies JA, Cachecho R, Dorlac WC: East practice management guidelines work group: Update to practice management guidelines for prophylactic antibiotic use in open fractures. J Trauma 2011;70:751-754.</ref><ref name=Garner2020/>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>		*Concern for [[clostridium]] (soil contamination, farm injuries, possible bowel contamination): additionally add [[penicillin]]<ref>HoffWS, Bonadies JA, Cachecho R, Dorlac WC: East practice management guidelines work group: Update to practice management guidelines for prophylactic antibiotic use in open fractures. J Trauma 2011;70:751-754.</ref><ref name=Garner2020>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>
	*Fresh water wounds: [[fluoroquinolones]] OR 3rd/4th generation [[cephalosporin]]		*Fresh water wounds: [[fluoroquinolones]] OR 3rd/4th generation [[cephalosporin]]
	*Saltwater wounds ([[vibrio]]): [[doxycycline]] + [[ceftazidime]] OR [[fluoroquinolone]]		*Saltwater wounds ([[vibrio]]): [[doxycycline]] + [[ceftazidime]] OR [[fluoroquinolone]]

Rossdonaldson1: /* Prophylactic Antibiotics for Open fractures */

2022-05-14T09:56:59Z

Prophylactic Antibiotics for Open fractures

← Older revision		Revision as of 09:56, 14 May 2022
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	====[[Open_fracture\|Grade I & II Fractures]] Options====		====[[Open_fracture\|Grade I & II Fractures]] Options====
	*[[Cefazolin]] (Ancef) 2 g IV (immediately and q8 hours x 3 total doses)<ref>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>		*[[Cefazolin]] (Ancef) 2 g IV (immediately and q8 hours x 3 total doses)<ref name=Garner2020/>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>
	*Cephalosporin allergy: [[clindamycin]] 900 mg IV (immediately and q8 hours x 3 total doses)<ref>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>		*Cephalosporin allergy: [[clindamycin]] 900 mg IV (immediately and q8 hours x 3 total doses)<ref name=Garner2020/>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>

	====[[Open_fracture#Grade_III\|Grade III Fracture]] Options====		====[[Open_fracture#Grade_III\|Grade III Fracture]] Options====
	*[[Ceftriaxone]] 2 g IV (immediately x 1 total dose) PLUS [[vancomycin]] 1 g IV (immediately and q12 hours x 2 total doses)<ref>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>		*[[Ceftriaxone]] 2 g IV (immediately x 1 total dose) PLUS [[vancomycin]] 1 g IV (immediately and q12 hours x 2 total doses)<ref name=Garner2020/>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>
	*Cephalosporin allergy: [[aztreonam]] 2 g IV (immediately and q8 hours x 3) PLUS [[vancomycin]] 1 g IV (immediately and q12 hours x 2 total doses)<ref>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>		*Cephalosporin allergy: [[aztreonam]] 2 g IV (immediately and q8 hours x 3) PLUS [[vancomycin]] 1 g IV (immediately and q12 hours x 2 total doses)<ref name=Garner2020/>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>

	====Special Considerations====		====Special Considerations====
	*Concern for [[clostridium]] (soil contamination, farm injuries, possible bowel contamination): additionally add [[penicillin]]<ref>HoffWS, Bonadies JA, Cachecho R, Dorlac WC: East practice management guidelines work group: Update to practice management guidelines for prophylactic antibiotic use in open fractures. J Trauma 2011;70:751-754.</ref><ref>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>		*Concern for [[clostridium]] (soil contamination, farm injuries, possible bowel contamination): additionally add [[penicillin]]<ref>HoffWS, Bonadies JA, Cachecho R, Dorlac WC: East practice management guidelines work group: Update to practice management guidelines for prophylactic antibiotic use in open fractures. J Trauma 2011;70:751-754.</ref><ref name=Garner2020/>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>
	*Fresh water wounds: [[fluoroquinolones]] OR 3rd/4th generation [[cephalosporin]]		*Fresh water wounds: [[fluoroquinolones]] OR 3rd/4th generation [[cephalosporin]]
	*Saltwater wounds ([[vibrio]]): [[doxycycline]] + [[ceftazidime]] OR [[fluoroquinolone]]		*Saltwater wounds ([[vibrio]]): [[doxycycline]] + [[ceftazidime]] OR [[fluoroquinolone]]

Rossdonaldson1: /* Special Considerations */

2022-05-14T09:54:25Z

Special Considerations

← Older revision		Revision as of 09:54, 14 May 2022
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	====Special Considerations====		====Special Considerations====
	*Concern for [[clostridium]] (soil contamination, farm injuries, possible bowel contamination)		*Concern for [[clostridium]] (soil contamination, farm injuries, possible bowel contamination): additionally add [[penicillin]]<ref>HoffWS, Bonadies JA, Cachecho R, Dorlac WC: East practice management guidelines work group: Update to practice management guidelines for prophylactic antibiotic use in open fractures. J Trauma 2011;70:751-754.</ref><ref>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>
	**Additionally add [[penicillin]]<ref>HoffWS, Bonadies JA, Cachecho R, Dorlac WC: East practice management guidelines work group: Update to practice management guidelines for prophylactic antibiotic use in open fractures. J Trauma 2011;70:751-754.</ref><ref>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>
	*Fresh water wounds: [[fluoroquinolones]] OR 3rd/4th generation [[cephalosporin]]		*Fresh water wounds: [[fluoroquinolones]] OR 3rd/4th generation [[cephalosporin]]
	*Saltwater wounds ([[vibrio]]): [[doxycycline]] + [[ceftazidime]] OR [[fluoroquinolone]]		*Saltwater wounds ([[vibrio]]): [[doxycycline]] + [[ceftazidime]] OR [[fluoroquinolone]]

← Older revision		Revision as of 13:16, 20 March 2026
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	*Fresh water wounds: [[fluoroquinolones\|fluoroquinolones]] OR 3rd/4th generation [[cephalosporin\|cephalosporin]]		*Fresh water wounds: [[fluoroquinolones\|fluoroquinolones]] OR 3rd/4th generation [[cephalosporin\|cephalosporin]]
	*Saltwater wounds ([[vibrio\|vibrio]]): [[doxycycline\|doxycycline]] + [[ceftazidime\|ceftazidime]] OR [[fluoroquinolone\|fluoroquinolone]]		*Saltwater wounds ([[vibrio\|vibrio]]): [[doxycycline\|doxycycline]] + [[ceftazidime\|ceftazidime]] OR [[fluoroquinolone\|fluoroquinolone]]

			====Pediatric====
			=====Grade I & II=====
			*{{AntibioticDose\|disease=Open fracture\|drug=Cefazolin\|dose=25mg/kg IV (max 2g) immediately then q8hrs x 3 doses\|context=Pediatric Grade I & II\|population=Pediatric}}
			*Cephalosporin allergy: {{AntibioticDose\|disease=Open fracture\|drug=Clindamycin\|dose=10mg/kg IV (max 900mg) immediately then q8hrs x 3 doses\|context=Pediatric Grade I & II, allergy\|population=Pediatric}}
			=====Grade III=====
			*{{AntibioticDose\|disease=Open fracture\|drug=Ceftriaxone\|dose=50mg/kg IV (max 2g) x 1\|context=Pediatric Grade III\|population=Pediatric}} + {{AntibioticDose\|disease=Open fracture\|drug=Vancomycin\|dose=15mg/kg IV (max 1g) then q12hrs x 2 doses\|context=Pediatric Grade III\|population=Pediatric}}
			*Cephalosporin allergy: {{AntibioticDose\|disease=Open fracture\|drug=Aztreonam\|dose=30mg/kg IV (max 2g) then q8hrs x 3\|context=Pediatric Grade III, allergy\|population=Pediatric}} + Vancomycin

← Older revision		Revision as of 02:53, 20 March 2026
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	~~<noinclude><languages/></noinclude>~~		===Prophylactic Antibiotics for [[Open fractures\|Open fractures]]===
	~~<translate>~~
	===Prophylactic Antibiotics for [[~~Special:MyLanguage/~~Open fractures\|Open fractures]]===

	~~<!--T:2-->~~
	''Initiate as soon as possible; increased infection rate when delayed<ref>Gosselin RA, et al. Antibiotics for preventing infection in open limb fractures. Cochrane Database Syst Rev. 2004; (1):CD003764.</ref>''		''Initiate as soon as possible; increased infection rate when delayed<ref>Gosselin RA, et al. Antibiotics for preventing infection in open limb fractures. Cochrane Database Syst Rev. 2004; (1):CD003764.</ref>''

	====[[~~Special:MyLanguage/~~Open_fracture\|Grade I & II Fractures]] Options====		====[[Open_fracture\|Grade I & II Fractures]] Options====

	~~<!--T:4-->~~
	*{{AntibioticDose\|disease=Open fracture\|drug=Cefazolin\|dose=2 g IV (immediately and q8 hours x 3 total doses)\|context=Grade I & II Fractures}} (Ancef)<ref name=Garner2020>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>		*{{AntibioticDose\|disease=Open fracture\|drug=Cefazolin\|dose=2 g IV (immediately and q8 hours x 3 total doses)\|context=Grade I & II Fractures}} (Ancef)<ref name=Garner2020>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>
	*Cephalosporin allergy: {{AntibioticDose\|disease=Open fracture\|drug=Clindamycin\|dose=900 mg IV (immediately and q8 hours x 3 total doses)\|context=Grade I & II, Cephalosporin allergy}}<ref name=Garner2020/>		*Cephalosporin allergy: {{AntibioticDose\|disease=Open fracture\|drug=Clindamycin\|dose=900 mg IV (immediately and q8 hours x 3 total doses)\|context=Grade I & II, Cephalosporin allergy}}<ref name=Garner2020/>

	====[[~~Special:MyLanguage/~~Open_fracture#Grade_III\|Grade III Fracture]] Options====		====[[Open_fracture#Grade_III\|Grade III Fracture]] Options====

	~~<!--T:6-->~~
	*{{AntibioticDose\|disease=Open fracture\|drug=Ceftriaxone\|dose=2 g IV (immediately x 1 total dose)\|context=Grade III Fractures}} PLUS {{AntibioticDose\|disease=Open fracture\|drug=Vancomycin\|dose=1 g IV (immediately and q12 hours x 2 total doses)\|context=Grade III Fractures}}<ref name=Garner2020/>		*{{AntibioticDose\|disease=Open fracture\|drug=Ceftriaxone\|dose=2 g IV (immediately x 1 total dose)\|context=Grade III Fractures}} PLUS {{AntibioticDose\|disease=Open fracture\|drug=Vancomycin\|dose=1 g IV (immediately and q12 hours x 2 total doses)\|context=Grade III Fractures}}<ref name=Garner2020/>
	*Cephalosporin allergy: {{AntibioticDose\|disease=Open fracture\|drug=Aztreonam\|dose=2 g IV (immediately and q8 hours x 3)\|context=Grade III, Cephalosporin allergy}} PLUS [[Vancomycin]] 1 g IV (immediately and q12 hours x 2 total doses)<ref name=Garner2020/>		*Cephalosporin allergy: {{AntibioticDose\|disease=Open fracture\|drug=Aztreonam\|dose=2 g IV (immediately and q8 hours x 3)\|context=Grade III, Cephalosporin allergy}} PLUS [[Vancomycin]] 1 g IV (immediately and q12 hours x 2 total doses)<ref name=Garner2020/>
Line 20:		Line 15:
	====Special Considerations====		====Special Considerations====

	~~<!--T:8-->~~		*Concern for [[clostridium\|clostridium]] (soil contamination, farm injuries, possible bowel contamination): additionally add [[penicillin\|penicillin]]<ref>HoffWS, Bonadies JA, Cachecho R, Dorlac WC: East practice management guidelines work group: Update to practice management guidelines for prophylactic antibiotic use in open fractures. J Trauma 2011;70:751-754.</ref><ref name=Garner2020/>
	*Concern for [[~~Special:MyLanguage/~~clostridium\|clostridium]] (soil contamination, farm injuries, possible bowel contamination): additionally add [[~~Special:MyLanguage/~~penicillin\|penicillin]]<ref>HoffWS, Bonadies JA, Cachecho R, Dorlac WC: East practice management guidelines work group: Update to practice management guidelines for prophylactic antibiotic use in open fractures. J Trauma 2011;70:751-754.</ref><ref name=Garner2020/>		*Fresh water wounds: [[fluoroquinolones\|fluoroquinolones]] OR 3rd/4th generation [[cephalosporin\|cephalosporin]]
	*Fresh water wounds: [[~~Special:MyLanguage/~~fluoroquinolones\|fluoroquinolones]] OR 3rd/4th generation [[~~Special:MyLanguage/~~cephalosporin\|cephalosporin]]		*Saltwater wounds ([[vibrio\|vibrio]]): [[doxycycline\|doxycycline]] + [[ceftazidime\|ceftazidime]] OR [[fluoroquinolone\|fluoroquinolone]]
	*Saltwater wounds ([[~~Special:MyLanguage/~~vibrio\|vibrio]]): [[~~Special:MyLanguage/~~doxycycline\|doxycycline]] + [[~~Special:MyLanguage/~~ceftazidime\|ceftazidime]] OR [[~~Special:MyLanguage/~~fluoroquinolone\|fluoroquinolone]]
	~~</translate>~~

← Older revision		Revision as of 08:32, 23 January 2026
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	<translate>		<translate>

	===Prophylactic Antibiotics for [[Special:MyLanguage/Open fractures\|Open fractures]]===		===Prophylactic Antibiotics for [[Special:MyLanguage/Open fractures\|Open fractures]]=== <!--T:1-->

			<!--T:2-->
	''Initiate as soon as possible; increased infection rate when delayed<ref>Gosselin RA, et al. Antibiotics for preventing infection in open limb fractures. Cochrane Database Syst Rev. 2004; (1):CD003764.</ref>''		''Initiate as soon as possible; increased infection rate when delayed<ref>Gosselin RA, et al. Antibiotics for preventing infection in open limb fractures. Cochrane Database Syst Rev. 2004; (1):CD003764.</ref>''


	====[[Special:MyLanguage/Open_fracture\|Grade I & II Fractures]] Options====		====[[Special:MyLanguage/Open_fracture\|Grade I & II Fractures]] Options==== <!--T:3-->

			<!--T:4-->
	*[[Special:MyLanguage/Cefazolin\|Cefazolin]] (Ancef) 2 g IV (immediately and q8 hours x 3 total doses)<ref name=Garner2020>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>		*[[Special:MyLanguage/Cefazolin\|Cefazolin]] (Ancef) 2 g IV (immediately and q8 hours x 3 total doses)<ref name=Garner2020>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>
	*Cephalosporin allergy: [[Special:MyLanguage/clindamycin\|clindamycin]] 900 mg IV (immediately and q8 hours x 3 total doses)<ref name=Garner2020>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>		*Cephalosporin allergy: [[Special:MyLanguage/clindamycin\|clindamycin]] 900 mg IV (immediately and q8 hours x 3 total doses)<ref name=Garner2020>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>


	====[[Special:MyLanguage/Open_fracture#Grade_III\|Grade III Fracture]] Options====		====[[Special:MyLanguage/Open_fracture#Grade_III\|Grade III Fracture]] Options==== <!--T:5-->

			<!--T:6-->
	*[[Special:MyLanguage/Ceftriaxone\|Ceftriaxone]] 2 g IV (immediately x 1 total dose) PLUS [[Special:MyLanguage/vancomycin\|vancomycin]] 1 g IV (immediately and q12 hours x 2 total doses)<ref name=Garner2020>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>		*[[Special:MyLanguage/Ceftriaxone\|Ceftriaxone]] 2 g IV (immediately x 1 total dose) PLUS [[Special:MyLanguage/vancomycin\|vancomycin]] 1 g IV (immediately and q12 hours x 2 total doses)<ref name=Garner2020>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>
	*Cephalosporin allergy: [[Special:MyLanguage/aztreonam\|aztreonam]] 2 g IV (immediately and q8 hours x 3) PLUS [[Special:MyLanguage/vancomycin\|vancomycin]] 1 g IV (immediately and q12 hours x 2 total doses)<ref name=Garner2020>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>		*Cephalosporin allergy: [[Special:MyLanguage/aztreonam\|aztreonam]] 2 g IV (immediately and q8 hours x 3) PLUS [[Special:MyLanguage/vancomycin\|vancomycin]] 1 g IV (immediately and q12 hours x 2 total doses)<ref name=Garner2020>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>


	====Special Considerations====		====Special Considerations==== <!--T:7-->

			<!--T:8-->
	*Concern for [[Special:MyLanguage/clostridium\|clostridium]] (soil contamination, farm injuries, possible bowel contamination): additionally add [[Special:MyLanguage/penicillin\|penicillin]]<ref>HoffWS, Bonadies JA, Cachecho R, Dorlac WC: East practice management guidelines work group: Update to practice management guidelines for prophylactic antibiotic use in open fractures. J Trauma 2011;70:751-754.</ref><ref name=Garner2020>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>		*Concern for [[Special:MyLanguage/clostridium\|clostridium]] (soil contamination, farm injuries, possible bowel contamination): additionally add [[Special:MyLanguage/penicillin\|penicillin]]<ref>HoffWS, Bonadies JA, Cachecho R, Dorlac WC: East practice management guidelines work group: Update to practice management guidelines for prophylactic antibiotic use in open fractures. J Trauma 2011;70:751-754.</ref><ref name=Garner2020>Garner MR, et al. Antibiotic Prophylaxis in Open Fractures: Evidence, Evolving Issues, and Recommendations. Journal of the American Academy of Orthopaedic Surgeons. April 15, 2020. 28(8):309-315</ref>
	*Fresh water wounds: [[Special:MyLanguage/fluoroquinolones\|fluoroquinolones]] OR 3rd/4th generation [[Special:MyLanguage/cephalosporin\|cephalosporin]]		*Fresh water wounds: [[Special:MyLanguage/fluoroquinolones\|fluoroquinolones]] OR 3rd/4th generation [[Special:MyLanguage/cephalosporin\|cephalosporin]]
	*Saltwater wounds ([[Special:MyLanguage/vibrio\|vibrio]]): [[Special:MyLanguage/doxycycline\|doxycycline]] + [[Special:MyLanguage/ceftazidime\|ceftazidime]] OR [[Special:MyLanguage/fluoroquinolone\|fluoroquinolone]]		*Saltwater wounds ([[Special:MyLanguage/vibrio\|vibrio]]): [[Special:MyLanguage/doxycycline\|doxycycline]] + [[Special:MyLanguage/ceftazidime\|ceftazidime]] OR [[Special:MyLanguage/fluoroquinolone\|fluoroquinolone]]
	</translate>		</translate>