Risperidone - Revision history

Elcatracho: /* See Also */

2021-03-07T04:10:41Z

ClaireLewis at 22:20, 23 September 2019

2019-09-23T22:20:00Z

← Older revision		Revision as of 22:20, 23 September 2019
Line 1:		Line 1:
	==Administration==		==Administration==
	*Type: Atypical antipsychotic		*Type: Atypical [[antipsychotic]]
	*Dosage Forms: 0.25mg, 0.5mg, 1mg, 2mg, 3mg, 4mg; 1mg/mL		*Dosage Forms: 0.25mg, 0.5mg, 1mg, 2mg, 3mg, 4mg; 1mg/mL
	*Routes of Administration: Oral, IM		*Routes of Administration: Oral, IM
Line 78:		Line 78:

	===Common===		===Common===
	*~~Akasthisia~~, dystonia, parkinsonism, tremor		*Akathisia, dystonia, parkinsonism, tremor
	*Sedation/[[fatigue]], [[dizziness]], blurred vision, [[anxiety]], confusion		*Sedation/[[fatigue]], [[dizziness]], blurred vision, [[anxiety]], confusion
	*[[Rash]]		*[[Rash]]
Line 102:		Line 102:
	<references/>		<references/>
	[[Category:Pharmacology]]		[[Category:Pharmacology]]
			[[Category:Psychiatry]]

Jonwarren: Update to dosing, adverse effects, pharmacology

2017-10-30T15:51:01Z

Update to dosing, adverse effects, pharmacology

← Older revision		Revision as of 15:51, 30 October 2017
Line 1:		Line 1:
	==Administration==		==Administration==
	*Type: Atypical antipsychotic		*Type: Atypical antipsychotic
	*Dosage Forms:		*Dosage Forms: 0.25mg, 0.5mg, 1mg, 2mg, 3mg, 4mg; 1mg/mL
	*Routes of Administration: Oral, IM		*Routes of Administration: Oral, IM
	*Common Trade Names: Risperdal		*Common Trade Names: Risperdal

	==Adult Dosing==		==Adult Dosing==
	*2-~~6mg~~ PO ~~daily~~		===[[Schizophrenia]]===
	*25-~~50mg IM~~		*<65 yo, 1st episode
			**1-3 mg/day PO divided qd/bid
			***Max: 16mg/day
			*<65 yo, maintenance
			**1-4 mg/day PO divided qd/bid
			*65+ yo
			**1-4 mg/day PO divided qd/bid
			***Doses >4 mg/day rarely more effective
			===[[Bipolar disorder]], Type 1, Acute manic===
			*1-6 mg/day PO divided qd/bid
			**Max: 6 mg/day
			===Tourette Syndrome===
			*0.25-3 mg/day PO divided qd-bid
			**Max 6 mg/day

	==Pediatric Dosing==		==Pediatric Dosing==
	*Pediatric procedural sedation: 0.01mg/kg/dose IM (typically 0.25-4mg/dose)		===Pediatric procedural sedation===
			*0.01mg/kg/dose IM (typically 0.25-4mg/dose)
			===[[Schizophrenia]]===
			*1-6 mg/day PO divided qd/bid
			===[[Bipolar disorder]], Type 1, Acute mania===
			*0.5-6mg/day PO divided qd/bid
			===Irritability, Autistic disorder associated===
			*0.5-3 mg/day PO divided qd/bid
			===Tourrette syndrome===
			*0.75-3 mg/day PO divided qd/bid

	==Special Populations==		==Special Populations==
	*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]: C		*[[Drug Ratings in Pregnancy\|Pregnancy Rating]]: C
	*[[Lactation risk categories\|Lactation risk]]: Infant risk cannot be ruled out		*[[Lactation risk categories\|Lactation risk]]: Infant risk cannot be ruled out
	*Renal: ~~severe impairment,~~ 0.5mg ~~twice daily~~, ~~titrate slowly~~		*Renal:
	*Hepatic: ~~lower initial dose~~		**Adult:
			***CrCl <30: Start 0.5 mg BID then increase by 0.5mg BID weekly
			***HD: Not defined
			**Pediatric:
			***Not defined, see adult dosing.
			*Hepatic:
			**Adult:
			***Child-Pugh Class C: Start 0.5 mg BID and increase by 0.5mg BID weekly
			**Pediatric:
			***Not defined, see adult dosing.

	==Contraindications==		==Contraindications==
	*Allergy to class/drug		*Allergy to class/drug
			*Caution:
			**Pediatric/adolescent pts
			**Pregnancy 3rd trimester
			**Elderly pts
			**Dementia-related psychosis
			**Renal impairment
			**Hepatic impairment
			**Parkinson's Disease
			**[[Neuroleptic malignant syndrome]] history
			**Seizure history
			**Cardiovascular disease
			**[[Diabetes mellitus]]
			**Suicide risk

	==Adverse Reactions==		==Adverse Reactions==
	===Serious===		===Serious===
	*~~Prolonged QT~~, ~~sudden cardiac death~~, ~~syncope~~		*[[Hypotension]], [[syncope]]
	*DKA		*Extrapyramidal symptoms: [[tardive dyskinesia]]
			*[[Neuroleptic malignant syndrome]], [[hyperthermia]]
			*[[Hyperglycemia]], [[diabetes mellitus]], [[DKA]]
			*[[Seizure]], [[Priapism]], [[Stroke]], [[TIA]]
			*Dysphagia
			*[[Leukopenia]], [[Neutropenia]], [[Agranulocytosis]]
			*Suicidality
	*[[Pancreatitis]]		*[[Pancreatitis]]
	*Cytopenias, TTP
	*Stroke, seizure, tardive dyskinesia, priapism
	*Neuroleptic malignant syndrome
	===Common===		===Common===
	*Akasthisia, dystonia, parkinsonism		*Akasthisia, dystonia, parkinsonism, tremor
	*Sedation/fatigue, dizziness, blurred vision, anxiety		*Sedation/[[fatigue]], [[dizziness]], blurred vision, [[anxiety]], confusion
	*Rash		*[[Rash]]
	*Hyperprolactinemia, weight gain, increased appetite		*Hyperprolactinemia, weight gain, increased appetite
	*Constipation, ~~diarrea~~, nausea/vomiting		*[[Constipation]], [[diarrhea]], [[nausea]]/[[vomiting]]
	*Cough, URI		*Urinary incontinence
			*[[Cough]], URI
			*[[Photosensitivity]], visual disturbance

	==Pharmacology==		==Pharmacology==
	*Half-life:		*Half-life: 20h (PO); 3-6 day (IM)
	*Metabolism: Hepatic, CYP2D6		*Metabolism: Hepatic, CYP2D6
	*Excretion:		*Excretion: Urine 70%, Feces 14%

	==Mechanism of Action==		==Mechanism of Action==

Rossdonaldson1: Text replacement - "Pancreatitis" to "Pancreatitis"

2016-09-25T21:06:11Z

Text replacement - "*Pancreatitis" to "*Pancreatitis"

← Older revision		Revision as of 21:06, 25 September 2016
Line 24:		Line 24:
	*Prolonged QT, sudden cardiac death, syncope		*Prolonged QT, sudden cardiac death, syncope
	*DKA		*DKA
	*Pancreatitis		*[[Pancreatitis]]
	*Cytopenias, TTP		*Cytopenias, TTP
	*Stroke, seizure, tardive dyskinesia, priapism		*Stroke, seizure, tardive dyskinesia, priapism

ClaireLewis: /* Pediatric Dosing */

2016-09-08T16:47:11Z

Pediatric Dosing

← Older revision		Revision as of 16:47, 8 September 2016
Line 9:		Line 9:
	*25-50mg IM		*25-50mg IM
	==Pediatric Dosing==		==Pediatric Dosing==
			*Pediatric procedural sedation: 0.01mg/kg/dose IM (typically 0.25-4mg/dose)

	==Special Populations==		==Special Populations==

ClaireLewis: Created page with "==Administration== Type: Atypical antipsychotic Dosage Forms: Routes of Administration: Oral, IM Common Trade Names: Risperdal ==Adult Dosing== 2-6mg PO daily 25-50mg I..."

2016-09-08T16:27:18Z

Created page with "==Administration== *Type: Atypical antipsychotic *Dosage Forms: *Routes of Administration: Oral, IM *Common Trade Names: Risperdal ==Adult Dosing== *2-6mg PO daily *25-50mg I..."

New page

==Administration==
*Type: Atypical antipsychotic
*Dosage Forms:
*Routes of Administration: Oral, IM
*Common Trade Names: Risperdal

==Adult Dosing==
*2-6mg PO daily
*25-50mg IM
==Pediatric Dosing==

==Special Populations==
*[[Drug Ratings in Pregnancy|Pregnancy Rating]]: C
*[[Lactation risk categories|Lactation risk]]: Infant risk cannot be ruled out
*Renal: severe impairment, 0.5mg twice daily, titrate slowly
*Hepatic: lower initial dose

==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
===Serious===
*Prolonged QT, sudden cardiac death, syncope
*DKA
*Pancreatitis
*Cytopenias, TTP
*Stroke, seizure, tardive dyskinesia, priapism
*Neuroleptic malignant syndrome
===Common===
*Akasthisia, dystonia, parkinsonism
*Sedation/fatigue, dizziness, blurred vision, anxiety
*Rash
*Hyperprolactinemia, weight gain, increased appetite
*Constipation, diarrea, nausea/vomiting
*Cough, URI

==Pharmacology==
*Half-life:
*Metabolism: Hepatic, CYP2D6
*Excretion:

==Mechanism of Action==
*Unknown
*5HT-2 inhibitor, weaker D2 inhibitor
==Comments==

==See Also==
[[Antipsychotics]]
==References==
<references/>
[[Category:Pharmacology]]

← Older revision		Revision as of 04:10, 7 March 2021
Line 98:		Line 98:

	==See Also==		==See Also==
	[[Antipsychotics]]		*[[Antipsychotics]]
			*[[Antipsychotic toxicity]]

	==References==		==References==
	<references/>		<references/>
	[[Category:Pharmacology]]		[[Category:Pharmacology]]
	[[Category:Psychiatry]]		[[Category:Psychiatry]]