Paraneoplastic syndromes - Revision history

ClaireLewis at 17:19, 1 October 2019

2019-10-01T17:19:22Z

ClaireLewis at 18:23, 16 August 2019

2019-08-16T18:23:26Z

← Older revision		Revision as of 18:23, 16 August 2019
Line 28:		Line 28:
	\| Opsoclonus myoclonus syndrome\|\|Neuroblastoma (occurs in 2-3% of peds cases), breast, ovarian, small-cell carcinoma\|\|Autoimmune; s/sx include opsoclonus/myoclonus and other cerebellar dysfunction, aphasia, lethargy/irritability		\| Opsoclonus myoclonus syndrome\|\|Neuroblastoma (occurs in 2-3% of peds cases), breast, ovarian, small-cell carcinoma\|\|Autoimmune; s/sx include opsoclonus/myoclonus and other cerebellar dysfunction, aphasia, lethargy/irritability
	\|-		\|-
	\| ~~Limbic or brain~~-stem [[encephalitis]]\|\|Small cell lung cancer, germ-cell testicular tumors\|\|Autoantibodies against intracellular neuronal proteins		\| Brain-stem or [[limbic encephalitis]]\|\|Small cell lung cancer, germ-cell testicular tumors\|\|Autoantibodies against intracellular neuronal proteins
	\|-		\|-
	\| [[Anti-NMDA receptor encephalitis]]\|\|Gyn tumors (esp. teratomas)\|\|Anti-NMDA receptor auto-antibodies		\| [[Anti-NMDA receptor encephalitis]]\|\|Gyn tumors (esp. teratomas)\|\|Anti-NMDA receptor auto-antibodies
Line 34:		Line 34:
	\| [[Polymyositis]]/[[Dermatomyositis]]\|\|[[Lymphoma]], lung, pancreatic, stomach, bladder, ovarian\|\|autoimmune		\| [[Polymyositis]]/[[Dermatomyositis]]\|\|[[Lymphoma]], lung, pancreatic, stomach, bladder, ovarian\|\|autoimmune
	\|-		\|-
	\| Acanthosis ~~igricans~~\|\|Gastric, lung, uterine\|\|Epidermal growth factor secretion		\| Acanthosis Nigricans\|\|Gastric, lung, uterine\|\|Epidermal growth factor secretion
	\|-		\|-
	\| Misc. derm conditions (Sweet's syndrome, Leser-Trelat sign, pyoderma gangrenosum, florid cutaneous papilomatosis, necrolytic migratory erythema, hypertrichosis)\|\|lung, GI adenocarcinomas, breast and GU cancers, lymphoma\|\|		\| Misc. derm conditions (Sweet's syndrome, Leser-Trelat sign, pyoderma gangrenosum, florid cutaneous papilomatosis, necrolytic migratory erythema, hypertrichosis)\|\|lung, GI adenocarcinomas, breast and GU cancers, lymphoma\|\|

ClaireLewis: Created page with "==Background== Syndrome associated with cancer, but not due to direct, local effects of neoplasm Result of hormones/substances secreted by malignant cells or immune response..."

2019-01-26T01:05:56Z

Created page with "==Background== *Syndrome associated with cancer, but not due to direct, local effects of neoplasm *Result of hormones/substances secreted by malignant cells or immune response..."

New page

==Background==
*Syndrome associated with cancer, but not due to direct, local effects of neoplasm
*Result of hormones/substances secreted by malignant cells or immune response to cancer cells/products

==Examples==

{| {{table}}
| align="center" style="background:#f0f0f0;"|'''Syndrome'''
| align="center" style="background:#f0f0f0;"|'''Main causal cancers'''
| align="center" style="background:#f0f0f0;"|'''Mechanism'''
|-
| [[Cushing syndrome]]||Small cell lung cancer, pancreatic carcinoma, neural tumors, thymoma||Ectopic ACTH/ACTH-like substance production
|-
| [[SIADH]]||Small cell lung cancer, CNS malignancies||Ectopic ADH production
|-
| [[Hypercalcemia of malignancy|Hypercalcemia]]||Lung (esp. SCC), breast, renal/bladder, ovarian, [[multiple myeloma]], adult T cell [[leukemia]]/[[lymphoma]], squamous cell carcinoma||
|-
| [[Hypoglycemia]]||Sarcomas, insulinoma, hepatocellular carcinoma||Insulin/IGF production
|-
| [[Carcinoid syndrome]]||Bronchial adenoma, pancreatic and gastric carcinoma||Serotonin or bradykinin production
|-
| Hyperaldosteronism||Adrenal adenoma, non-Hodgkin's [[lymphoma]], ovarian carcinoma, lung cancer||increased/ectopic aldosterone production
|-
| [[Lambert-Eaton myasthenic syndrome]]||Small cell lung cancer||Immune-mediated
|-
| Paraneoplastic cerebellar degeneration||Lung, ovarian, breast cancers, Hodgkin's [[llymphoma]]||
|-
| Opsoclonus myoclonus syndrome||Neuroblastoma (occurs in 2-3% of peds cases), breast, ovarian, small-cell carcinoma||Autoimmune; s/sx include opsoclonus/myoclonus and other cerebellar dysfunction, aphasia, lethargy/irritability
|-
| Limbic or brain-stem [[encephalitis]]||Small cell lung cancer, germ-cell testicular tumors||Autoantibodies against intracellular neuronal proteins
|-
| [[Anti-NMDA receptor encephalitis]]||Gyn tumors (esp. teratomas)||Anti-NMDA receptor auto-antibodies
|-
| [[Polymyositis]]/[[Dermatomyositis]]||[[Lymphoma]], lung, pancreatic, stomach, bladder, ovarian||autoimmune
|-
| Acanthosis igricans||Gastric, lung, uterine||Epidermal growth factor secretion
|-
| Misc. derm conditions (Sweet's syndrome, Leser-Trelat sign, pyoderma gangrenosum, florid cutaneous papilomatosis, necrolytic migratory erythema, hypertrichosis)||lung, GI adenocarcinomas, breast and GU cancers, lymphoma||
|-
| [[VTE]], thrombophlebitis||any advanced cancer. Pancreatic and bronchogenic carcinomas associated w/troussau's sign||Hypercoaguability
|-
| Polycythemia||Renal cell carcioma, cerebellar hemangioma, hepatocellular carcinoma||Increased erythropoiten production
|-
| Granulocytosis||various||C-GSF
|-
| Membranous glomerulonephritis||||tumor antigens/immune complexes
|-
| Thymoma-associated multiorgan autoimmunity||Thymoma||similar to [[GVHD]]
|}

==References==
<references/>

[[Category:Heme/Onc]]

← Older revision		Revision as of 17:19, 1 October 2019
Line 14:		Line 14:
	\| [[SIADH]]\|\|Small cell lung cancer, CNS malignancies\|\|Ectopic ADH production		\| [[SIADH]]\|\|Small cell lung cancer, CNS malignancies\|\|Ectopic ADH production
	\|-		\|-
	\| [[Hypercalcemia of malignancy\|Hypercalcemia]]\|\|Lung (esp. SCC), breast, renal/bladder, ovarian, [[multiple myeloma]], adult T cell [[leukemia]]/[[lymphoma]], squamous cell carcinoma\|\|		\| [[Hypercalcemia of malignancy\|Hypercalcemia]]\|\|Lung (esp. [[squamous cell carcinoma\|SCC]]), breast, renal/bladder, ovarian, [[multiple myeloma]], adult T cell [[leukemia]]/[[lymphoma]], [[squamous cell carcinoma]]\|\|
	\|-		\|-
	\| [[Hypoglycemia]]\|\|Sarcomas, insulinoma, hepatocellular carcinoma\|\|Insulin/IGF production		\| [[Hypoglycemia]]\|\|Sarcomas, insulinoma, [[hepatocellular carcinoma]]\|\|Insulin/IGF production
	\|-		\|-
	\| [[Carcinoid syndrome]]\|\|Bronchial adenoma, pancreatic and gastric carcinoma\|\|Serotonin or bradykinin production		\| [[Carcinoid syndrome]]\|\|Bronchial adenoma, pancreatic and gastric carcinoma\|\|Serotonin or bradykinin production
	\|-		\|-
	\| Hyperaldosteronism\|\|Adrenal adenoma, non-Hodgkin's [[lymphoma]], ovarian carcinoma, lung cancer\|\|increased/ectopic aldosterone production		\| Hyperaldosteronism\|\|Adrenal adenoma, [[non-Hodgkin's lymphoma]], ovarian carcinoma, lung cancer\|\|increased/ectopic aldosterone production
	\|-		\|-
	\| [[Lambert-Eaton myasthenic syndrome]]\|\|Small cell lung cancer\|\|Immune-mediated		\| [[Lambert-Eaton myasthenic syndrome]]\|\|Small cell lung cancer\|\|Immune-mediated
	\|-		\|-
	\| Paraneoplastic cerebellar degeneration\|\|Lung, ovarian, breast cancers, Hodgkin's ~~[[llymphoma~~]]\|\|		\| Paraneoplastic cerebellar degeneration\|\|Lung, ovarian, breast cancers, [[Hodgkin's lymphoma]]\|\|
	\|-		\|-
	\| Opsoclonus myoclonus syndrome\|\|Neuroblastoma (occurs in 2-3% of peds cases), breast, ovarian, small-cell carcinoma\|\|Autoimmune; s/sx include opsoclonus/myoclonus and other cerebellar dysfunction, aphasia, lethargy/irritability		\| [[Opsoclonus]] myoclonus syndrome\|\|[[neuroblastoma (peds)\|Neuroblastoma]] (occurs in 2-3% of peds cases), breast, ovarian, small-cell carcinoma\|\|Autoimmune; s/sx include opsoclonus/myoclonus and other cerebellar dysfunction, aphasia, lethargy/irritability
	\|-		\|-
	\| Brain-stem or [[limbic encephalitis]]\|\|Small cell lung cancer, germ-cell testicular tumors\|\|Autoantibodies against intracellular neuronal proteins		\| Brain-stem or [[limbic encephalitis]]\|\|Small cell lung cancer, germ-cell testicular tumors\|\|Autoantibodies against intracellular neuronal proteins
Line 34:		Line 34:
	\| [[Polymyositis]]/[[Dermatomyositis]]\|\|[[Lymphoma]], lung, pancreatic, stomach, bladder, ovarian\|\|autoimmune		\| [[Polymyositis]]/[[Dermatomyositis]]\|\|[[Lymphoma]], lung, pancreatic, stomach, bladder, ovarian\|\|autoimmune
	\|-		\|-
	\| Acanthosis ~~Nigricans~~\|\|Gastric, lung, uterine\|\|Epidermal growth factor secretion		\| [[Acanthosis nigricans]]\|\|Gastric, lung, uterine\|\|Epidermal growth factor secretion
	\|-		\|-
	\| Misc. derm conditions (Sweet's syndrome, Leser-Trelat sign, pyoderma gangrenosum, florid cutaneous ~~papilomatosis~~, necrolytic migratory erythema, hypertrichosis)\|\|lung, GI adenocarcinomas, breast and GU cancers, lymphoma\|\|		\| Misc. derm conditions (Sweet's syndrome, Leser-Trelat sign, [[pyoderma gangrenosum]], florid cutaneous papillomatosis, necrolytic migratory erythema, hypertrichosis)\|\|lung, GI adenocarcinomas, breast and GU cancers, [[lymphoma]]\|\|
	\|-		\|-
	\| [[VTE]], thrombophlebitis\|\|any advanced cancer. Pancreatic and bronchogenic carcinomas associated w/~~troussau~~'s sign\|\|~~Hypercoaguability~~		\| [[VTE]], [[thrombophlebitis]]\|\|any advanced cancer. Pancreatic and bronchogenic carcinomas associated w/trousseau's sign\|\|Hypercoagulability
	\|-		\|-
	\| Polycythemia\|\|Renal cell ~~carcioma~~, cerebellar hemangioma, hepatocellular carcinoma\|\|Increased ~~erythropoiten~~ production		\| [[Polycythemia]]\|\|Renal cell carcinoma, cerebellar hemangioma, [[hepatocellular carcinoma]]\|\|Increased erythropoietin production
	\|-		\|-
	\| Granulocytosis\|\|various\|\|C-GSF		\| Granulocytosis\|\|various\|\|C-GSF
	\|-		\|-
	\| Membranous glomerulonephritis\|\|\|\|tumor antigens/immune complexes		\| Membranous [[glomerulonephritis]]\|\|\|\|tumor antigens/immune complexes
	\|-		\|-
	\| Thymoma-associated multiorgan autoimmunity\|\|Thymoma\|\|similar to [[GVHD]]		\| Thymoma-associated multiorgan autoimmunity\|\|Thymoma\|\|similar to [[GVHD]]

Paraneoplastic syndromes - Revision history

ClaireLewis at 17:19, 1 October 2019

ClaireLewis at 18:23, 16 August 2019

ClaireLewis: Created page with "==Background== *Syndrome associated with cancer, but not due to direct, local effects of neoplasm *Result of hormones/substances secreted by malignant cells or immune response..."

ClaireLewis: Created page with "==Background== Syndrome associated with cancer, but not due to direct, local effects of neoplasm Result of hormones/substances secreted by malignant cells or immune response..."