https://wikem.org/w/index.php?action=history&feed=atom&title=Nadalol 2026-04-18T09:00:21Z Revision history for this page on the wiki MediaWiki 1.38.2 https://wikem.org/w/index.php?title=Nadalol&diff=229817&oldid=prev 2019-09-24T03:27:06Z

<p>Created page with &quot;==Administration== *Type: <a href="/wiki/Beta_blocker" class="mw-redirect" title="Beta blocker">beta blocker</a> *Dosage Forms: *Routes of Administration: PO *Common Trade Names: ==Adult Dosing== *40-160mg PO daily ==Pediatric Dosing== ==Sp...&quot;</p> <p><b>New page</b></p><div>==Administration==<br /> *Type: [[beta blocker]]<br /> *Dosage Forms:<br /> *Routes of Administration: PO<br /> *Common Trade Names: <br /> <br /> ==Adult Dosing==<br /> *40-160mg PO daily<br /> <br /> ==Pediatric Dosing==<br /> <br /> <br /> ==Special Populations==<br /> ===[[Drug pregnancy categories|Pregnancy Rating]]===<br /> *C<br /> <br /> ===Lactation risk===<br /> *Excreted in breastmilk. AAP says compatible with breastfeeding&lt;ref&gt;https://reference.medscape.com/drug/corgard-nadolol-342361#6&lt;/ref&gt;<br /> <br /> ===Renal Dosing===<br /> *CrCl 31-50 mL/min: Give q24-36hr<br /> *CrCl 10-30 mL/min: Give q24-48hr<br /> *CrCl &lt;10 mL/min: Give q40-60hr===Hepatic Dosing===<br /> <br /> ==Contraindications==<br /> *Allergy to class/drug<br /> *Overt cardiac failure, 2°/3° heart block, cardiogenic shock<br /> *Asthma/COPD<br /> *Avoid during breastfeeding<br /> *Sinus bradycardia<br /> *Sick sinus syndrome without permanent pacemaker<br /> *Caution if:<br /> **Nonallergenic bronchospasm<br /> **Cerebrovascular insufficiency<br /> *Well-compensated CHF<br /> *DM<br /> **Hyperthyroidism/thyrotoxicosis<br /> **Liver disease<br /> **Renal impairment<br /> **Peripheral vascular disease<br /> **Planned surgery<br /> **Pheochromocytoma<br /> **Abrupt cessation may lead to worsened angina and myocardial infarction<br /> <br /> ==Adverse Reactions==<br /> ===Serious===<br /> *Bronchospasm<br /> *Hypotension<br /> <br /> ===Common===<br /> *Drowsiness, insomnia<br /> *Decreased sexual ability<br /> *Bradycardia<br /> *Dizziness, fatigue<br /> *Hypotension<br /> *Abdominal discomfort, constipation, diarrhea, nausea<br /> *Cough, nasal congestion<br /> *Bronchospasm<br /> *Depression<br /> *Decreased exercise tolerance<br /> *Raynaud's phenomenon<br /> *Increased triglycerides and insulin resistance, decreased HDL<br /> <br /> May increase triglyceride levels and insulin resistance, and decrease HDL levels<br /> <br /> ==Pharmacology==<br /> *Half-life: 10-24h<br /> *Metabolism: none<br /> *Excretion: urine<br /> <br /> ==Mechanism of Action==<br /> *Blocks response to beta-adrenergic stimulation to beta1 and beta2 receptors; may reduce portal pressure through beta2 receptor, which reduces portal blood flow<br /> <br /> ==Comments==<br /> <br /> <br /> ==See Also==<br /> <br /> <br /> ==References==<br /> &lt;references/&gt;<br /> <br /> [[Category:Pharmacology]]<br /> [[Category:Cardiology]]</div>

ClaireLewis