Lomotil toxicity - Revision history

Rossdonaldson1 at 22:02, 27 March 2024

2024-03-27T22:02:42Z

2024-03-27T22:02:07Z

Background

← Older revision		Revision as of 22:02, 27 March 2024
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	**[[Opioid]] analog of [[meperidine]], which has opioid-like toxicity in overdose		**[[Opioid]] analog of [[meperidine]], which has opioid-like toxicity in overdose
	*[[Atropine]]		*[[Atropine]]
	**[[~~anticholinergic~~ effects		**[[Anticholinergic effects]]
	*Toxic dose is variable		*Toxic dose is variable

			{{Anticholinergic types}}

	==Clinical Features==		==Clinical Features==

2019-09-14T14:42:59Z

← Older revision		Revision as of 14:42, 14 September 2019
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	==Background==		==Background==
	*Mixture of diphenoxylate / atropine used to treat diarrhea		*Mixture of [[diphenoxylate/atropine]] used to treat diarrhea
	*Children are especially sensitive to toxicity (death reported after ingestion of <5 tablets)		*Children are especially sensitive to toxicity (death reported after ingestion of <5 tablets)

	===Mechanism of toxicity===		===Mechanism of toxicity===
	*Diphenoxylate		*[[Diphenoxylate]]
	**~~opioid~~ analog of meperidine, which has opioid-like toxicity in overdose		**[[Opioid]] analog of [[meperidine]], which has opioid-like toxicity in overdose
	*[[Atropine]]		*[[Atropine]]
	**anticholinergic effects		**[[anticholinergic effects
	*Toxic dose is variable		*Toxic dose is variable

	==Clinical Features==		==Clinical Features==
	*Atropine effects		*Atropine effects
	**Lethargy, agitation, flushing, dry mucous membranes, mydriasis, ileus, tachycardia		**[[Lethargy]], [[agitation]], flushing, dry mucous membranes, mydriasis, [[ileus]], [[tachycardia]]
	*Opioid effects		*Opioid effects
	**Miosis, coma, respiratory depression, respiratory arrest		**Miosis, [[coma]], respiratory depression, [[respiratory arrest]]

	==Differential Diagnosis==		==Differential Diagnosis==
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	==See Also==		==See Also==
	*[[Opioid toxicity]]		*[[Opioid toxicity]]
			*[[Diphenoxylate/atropine]]

	==References==		==References==

2016-12-13T21:51:19Z

2016-12-13T21:48:35Z

Differential Diagnosis

← Older revision		Revision as of 21:48, 13 December 2016
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	==Differential Diagnosis==		==Differential Diagnosis==
	{{Sedatve/hypnotic toxicity types}}		{{Sedatve/hypnotic toxicity types}}

			{{Anticholinergic types}}

	==Evaluation==		==Evaluation==

2016-12-13T21:46:19Z

Differential Diagnosis

← Older revision		Revision as of 21:46, 13 December 2016
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	==Differential Diagnosis==		==Differential Diagnosis==
			{{Sedatve/hypnotic toxicity types}}

	==Evaluation==		==Evaluation==

2016-12-13T21:45:36Z

Management

← Older revision		Revision as of 21:45, 13 December 2016
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	==Management==		==Management==
	*Maintain airway and support ventilation, if needed		*Maintain airway and support [[ventilation]], if needed
	*[[Naloxone]] 1-2mg IV for apnea, coma, or lethargy (may require repeat dosing)		*[[Naloxone]] 1-2mg IV for apnea, coma, or lethargy (may require repeat dosing)
	*[[Activated charcoal]] should be given promptly if available		*[[Activated charcoal]] should be given promptly if available

2016-12-13T21:45:26Z

Management

← Older revision		Revision as of 21:45, 13 December 2016
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	==Management==		==Management==
	*Maintain airway and support ventilation, if needed		*Maintain airway and support ventilation, if needed
	*Naloxone 1-2mg IV for apnea, coma, or lethargy (may require repeat dosing)		*[[Naloxone]] 1-2mg IV for apnea, coma, or lethargy (may require repeat dosing)
	*~~No evidence for utility of physostigmine~~		*[[Activated charcoal]] should be given promptly if available
	*Activated charcoal should be given promptly if available		*No evidence for utility of [[physostigmine]]

	==Disposition==		==Disposition==

2016-12-13T21:44:52Z

← Older revision		Revision as of 21:44, 13 December 2016
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	*Children are especially sensitive to toxicity (death reported after ingestion of <5 tablets)		*Children are especially sensitive to toxicity (death reported after ingestion of <5 tablets)

	==Mechanism of toxicity==		===Mechanism of toxicity===
	*Diphenoxylate		*Diphenoxylate
	**opioid analog of meperidine, which has opioid-like toxicity in overdose		**opioid analog of meperidine, which has opioid-like toxicity in overdose
	*Atropine		*[[Atropine]]
	**anticholinergic effects		**anticholinergic effects
	*Toxic dose is variable		*Toxic dose is variable
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	*Opioid effects		*Opioid effects
	**Miosis, coma, respiratory depression, respiratory arrest		**Miosis, coma, respiratory depression, respiratory arrest

			==Differential Diagnosis==

	==Evaluation==		==Evaluation==
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	==Disposition==		==Disposition==
	*Pediatric patients should be observed in the ICU for 24 hours given risk of sudden respiratory arrest		*Pediatric patients should be observed in the ICU for 24 hours given risk of sudden respiratory arrest

			==See Also==

	==References==		==References==

2016-12-13T21:43:35Z

← Older revision	Revision as of 21:43, 13 December 2016
(No difference)