Kaposi's sarcoma - Revision history

Danbot: Add peer-reviewed reference

2026-03-22T10:16:19Z

Add peer-reviewed reference

← Older revision		Revision as of 10:16, 22 March 2026
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	==Differential Diagnosis==		==Differential Diagnosis==
	*Cutaneous Lesions:		*Cutaneous Lesions:<ref>Cesarman E, et al. Kaposi sarcoma. Nat Rev Dis Primers. 2019;5(1):9. PMID 30705286</ref>
	**Bacillary angiomatosis		**Bacillary angiomatosis
	**[[Purpura]]		**[[Purpura]]

Rossdonaldson1: /* Background */

2024-12-11T16:36:05Z

Background

← Older revision		Revision as of 16:36, 11 December 2024
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	==Background==		==Background==
			{{Skin anatomy background images}}
	*Different classifications of Kaposi’s sarcoma based on patient population		*Different classifications of Kaposi’s sarcoma based on patient population
	*Associated with [[HHV-8]]		*Associated with [[HHV-8]]

Rossdonaldson1: /* Background */

2023-07-12T21:21:52Z

Background

← Older revision		Revision as of 21:21, 12 July 2023
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	==Background==		==Background==
	*Different classifications of Kaposi’s sarcoma based on patient population		*Different classifications of Kaposi’s sarcoma based on patient population
	*Associated with HHV-8		*Associated with [[HHV-8]]
	*Most common cancer in [[HIV]]/[[AIDS]] patients		*Most common cancer in [[HIV]]/[[AIDS]] patients
	*Kaposi’s Sarcoma can be unmasked or induced by initiation of steroids or HAART		*Kaposi’s Sarcoma can be unmasked or induced by initiation of steroids or HAART

Rossdonaldson1: /* Clinical Features */

2020-09-10T18:31:27Z

Clinical Features

← Older revision		Revision as of 18:31, 10 September 2020
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	[[File:Kaposis Sarcoma Lesions.jpg\|thumb\|Kaposi's sarcoma skin lesion]]		[[File:Kaposis Sarcoma Lesions.jpg\|thumb\|Kaposi's sarcoma skin lesion]]
	[[File:Patch stage Kaposi's sarcoma.jpg\|thumb\|Patch stage Kaposi's sarcoma. Red to brownish irregularly shaped macules and plaques.]]		[[File:Patch stage Kaposi's sarcoma.jpg\|thumb\|Patch stage Kaposi's sarcoma. Red to brownish irregularly shaped macules and plaques.]]
			[[File:Kaposi’s sarcoma intraoral AIDS 072 lores.jpg\|thumb\|An HIV-positive person presenting with a Kaposi's sarcoma lesion with an overlying candidiasis infection in their mouth.]]
	*[[rash\|Cutaneous]]		*[[rash\|Cutaneous]]
	*Heterogeneous appearance		*Heterogeneous appearance

Rossdonaldson1: /* Clinical Features */

2020-09-10T18:30:13Z

Clinical Features

← Older revision		Revision as of 18:30, 10 September 2020
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	[[File:Kaposis sarcoma 01.jpg\|thumb\|Kaposi sarcoma. Characteristic purple lesions on the nose in an HIV-positive female.]]		[[File:Kaposis sarcoma 01.jpg\|thumb\|Kaposi sarcoma. Characteristic purple lesions on the nose in an HIV-positive female.]]
	[[File:Kaposis Sarcoma Lesions.jpg\|thumb\|Kaposi's sarcoma skin lesion]]		[[File:Kaposis Sarcoma Lesions.jpg\|thumb\|Kaposi's sarcoma skin lesion]]
			[[File:Patch stage Kaposi's sarcoma.jpg\|thumb\|Patch stage Kaposi's sarcoma. Red to brownish irregularly shaped macules and plaques.]]
	*[[rash\|Cutaneous]]		*[[rash\|Cutaneous]]
	*Heterogeneous appearance		*Heterogeneous appearance

Rossdonaldson1: /* Clinical Features */

2020-09-10T18:26:41Z

Clinical Features

← Older revision		Revision as of 18:26, 10 September 2020
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	==Clinical Features==		==Clinical Features==
			[[File:Kaposis sarcoma 01.jpg\|thumb\|Kaposi sarcoma. Characteristic purple lesions on the nose in an HIV-positive female.]]
	[[File:Kaposis Sarcoma Lesions.jpg\|thumb\|Kaposi's sarcoma skin lesion]]		[[File:Kaposis Sarcoma Lesions.jpg\|thumb\|Kaposi's sarcoma skin lesion]]
	*[[rash\|Cutaneous]]		*[[rash\|Cutaneous]]

Rossdonaldson1: /* Differential Diagnosis */

2019-11-16T12:35:16Z

Differential Diagnosis

← Older revision		Revision as of 12:35, 16 November 2019
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	{{HIV associated conditions}}		{{HIV associated conditions}}
			{{DDX dark raised lesions}}

	==Evaluation==		==Evaluation==

ClaireLewis at 22:54, 27 September 2019

2019-09-27T22:54:59Z

← Older revision		Revision as of 22:54, 27 September 2019
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	*Different classifications of Kaposi’s sarcoma based on patient population		*Different classifications of Kaposi’s sarcoma based on patient population
	*Associated with HHV-8		*Associated with HHV-8
	*Most common cancer in HIV/AIDS patients		*Most common cancer in [[HIV]]/[[AIDS]] patients
	*Kaposi’s Sarcoma can be unmasked or induced by initiation of steroids or HAART		*Kaposi’s Sarcoma can be unmasked or induced by initiation of steroids or HAART
	*Cutaneous lower extremity lesions most common presentation		*Cutaneous lower extremity lesions most common presentation
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	==Clinical Features==		==Clinical Features==
	[[File:Kaposis Sarcoma Lesions.jpg\|thumb\|Kaposi's sarcoma skin lesion]]		[[File:Kaposis Sarcoma Lesions.jpg\|thumb\|Kaposi's sarcoma skin lesion]]
	*Cutaneous		*[[rash\|Cutaneous]]
	*Heterogeneous appearance		*Heterogeneous appearance
	**Color – dark blue, reddish, purple, violaceous, dark brown/black		**Color – dark blue, reddish, purple, violaceous, dark brown/black
	**Location – extremities, most commonly the feet		**Location – extremities, most commonly the feet
	**Lesions: macules, plaques, nodules		**Lesions: macules, plaques, nodules
	**Associated lymphedema		**Associated [[lymphedema]]
	*Pulmonary		*Pulmonary
	**Gradual Onset (2-4 weeks)		**Gradual Onset (2-4 weeks)
	**Cough		**[[Cough]]
	**[[Dyspnea]]		**[[Dyspnea]]
	**[[Fever]]		**[[Fever]]
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	**Asymptomatic		**Asymptomatic
	*Gastrointestinal		*Gastrointestinal
	**Bleeding		**[[GI bleed\|Bleeding]]
	**Obstruction		**[[SBO\|Obstruction]]

	==Differential Diagnosis==		==Differential Diagnosis==
	*Cutaneous Lesions:		*Cutaneous Lesions:
	**Bacillary angiomatosis		**Bacillary angiomatosis
	**Purpura		**[[Purpura]]
	**Hematomas		**Hematomas
	**Angiomas		**Angiomas
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	**Nevi		**Nevi
	*Pulmonary Lesions in HIV/AIDs:		*Pulmonary Lesions in HIV/AIDs:
	**Bacterial ~~Pneumonia~~		**Bacterial [[pneumonia]]
	**PCP		**[[PCP pneumonia\|PCP]]
	**TB		**[[TB]]
	**Fungal ~~Infections~~		**[[Fungal infections]]
	*Anorectal Lesions in HIV/AIDs:		*Anorectal Lesions in HIV/AIDs:
	**Common: Anal fissure, ~~Abscess~~ and/or fistula, ~~Hemorrhoid~~, ~~Pilonidal~~ disease		**Common: [[Anal fissure]], [[perianal abscess\|abscess]] and/or fistula, [[hemorrhoid]], [[pilonidal cyst\|[pilonidal disease]]
	**STDs: Gonorrhea, ~~Chlamydial infection~~, ~~Herpes~~, ~~Chancroid~~, ~~Syphilis~~, ~~Condyloma acuminatum~~		**STDs: [[Gonorrhea]], [[chlamydia]], [[HSV\|herpes]], [[chancroid]], [[syphilis]], [[condyloma acuminata]]
	**Infectious: TB, CMV infection, actinomycosis, cryptococcosis		**Infectious: [[TB]], [[CMV]] infection, [[actinomyces\|actinomycosis]], [[cryptococcosis]]
	**Neoplastic: Lymphoma, Kaposi’s sarcoma, squamous cell carcinoma		**Neoplastic: [[Lymphoma]], [[Kaposi’s sarcoma]], [[squamous cell carcinoma]]

	{{HIV associated conditions}}		{{HIV associated conditions}}
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	**Unlikely visible on XR; can be seen on flex sig or colonoscopy		**Unlikely visible on XR; can be seen on flex sig or colonoscopy
	*Pulmonary Manifestations		*Pulmonary Manifestations
	**Heterogeneous on XR - nodular, interstitial and/or alveolar infiltrates, pleural effusion, hilar and/or mediastinal adenopathy, or an isolated nodule		**Heterogeneous on [[CXR]] - nodular, interstitial and/or alveolar infiltrates, pleural effusion, hilar and/or mediastinal adenopathy, or an isolated nodule

	===Staging===		===Staging===
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	**Bevacizumab - an anti-VEGF-A		**Bevacizumab - an anti-VEGF-A
	**Imatinib - monoclonal antibody tyrosine kinase receptor		**Imatinib - monoclonal antibody tyrosine kinase receptor
	*Steroids		*[[Steroids]]
	**Associated with generation and exacerbation of KS		**Associated with generation and exacerbation of KS
	**Important implications because of the high use of steroids in this patient population (HIV/AIDS, transplant)		**Important implications because of the high use of steroids in this patient population (HIV/AIDS, transplant)

Neil.m.young: Text replacement - "==Diagnosis==" to "==Evaluation=="

2016-07-23T21:30:26Z

Text replacement - "==Diagnosis==" to "==Evaluation=="

← Older revision		Revision as of 21:30, 23 July 2016
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	{{HIV associated conditions}}		{{HIV associated conditions}}

	==~~Diagnosis~~==		==Evaluation==
	*Clinical impression		*Clinical impression
	*Biopsy is gold standard for definitive diagnosis		*Biopsy is gold standard for definitive diagnosis

Neil.m.young: Text replacement - "0 mg" to "0mg"

2016-07-20T13:01:34Z

Text replacement - "0 mg" to "0mg"

← Older revision		Revision as of 13:01, 20 July 2016
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	**Can combine with chemotherapy		**Can combine with chemotherapy
	*Chemotherapy:		*Chemotherapy:
	**First-line: Pegylated liposomal doxorubicin (PLD) ~~20 mg~~/m2 every three weeks (unless cardiac contraindication)		**First-line: Pegylated liposomal doxorubicin (PLD) 20mg/m2 every three weeks (unless cardiac contraindication)
	**Second-line: Vinblastine, Bleomycin, Paclitaxel, Etoposide, Gemcitabine		**Second-line: Vinblastine, Bleomycin, Paclitaxel, Etoposide, Gemcitabine
	*Cutaneous Specific Treatment:		*Cutaneous Specific Treatment:

← Older revision		Revision as of 18:31, 10 September 2020
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	[[File:Kaposis Sarcoma Lesions.jpg\|thumb\|Kaposi's sarcoma skin lesion]]		[[File:Kaposis Sarcoma Lesions.jpg\|thumb\|Kaposi's sarcoma skin lesion]]
	[[File:Patch stage Kaposi's sarcoma.jpg\|thumb\|Patch stage Kaposi's sarcoma. Red to brownish irregularly shaped macules and plaques.]]		[[File:Patch stage Kaposi's sarcoma.jpg\|thumb\|Patch stage Kaposi's sarcoma. Red to brownish irregularly shaped macules and plaques.]]
			[[File:Kaposi’s sarcoma intraoral AIDS 072 lores.jpg\|thumb\|An HIV-positive person presenting with a Kaposi's sarcoma lesion with an overlying candidiasis infection in their mouth.]]
	*[[rash\|Cutaneous]]		*[[rash\|Cutaneous]]
	*Heterogeneous appearance		*Heterogeneous appearance

← Older revision		Revision as of 18:30, 10 September 2020
Line 47:		Line 47:
	[[File:Kaposis sarcoma 01.jpg\|thumb\|Kaposi sarcoma. Characteristic purple lesions on the nose in an HIV-positive female.]]		[[File:Kaposis sarcoma 01.jpg\|thumb\|Kaposi sarcoma. Characteristic purple lesions on the nose in an HIV-positive female.]]
	[[File:Kaposis Sarcoma Lesions.jpg\|thumb\|Kaposi's sarcoma skin lesion]]		[[File:Kaposis Sarcoma Lesions.jpg\|thumb\|Kaposi's sarcoma skin lesion]]
			[[File:Patch stage Kaposi's sarcoma.jpg\|thumb\|Patch stage Kaposi's sarcoma. Red to brownish irregularly shaped macules and plaques.]]
	*[[rash\|Cutaneous]]		*[[rash\|Cutaneous]]
	*Heterogeneous appearance		*Heterogeneous appearance