Gyromitra mushrooms - Revision history

ClaireLewis: /* ManagementDiaz JH. Syndromic diagnosis and management of confirmed mushroom poisonings. Crit Care Med. 2005 Feb. 33(2):427-36. */

2021-02-08T15:37:17Z

ManagementDiaz JH. Syndromic diagnosis and management of confirmed mushroom poisonings. Crit Care Med. 2005 Feb. 33(2):427-36.

← Older revision		Revision as of 15:37, 8 February 2021
Line 37:		Line 37:
	*Avoid [[phenobarbital]], especially in liver failure		*Avoid [[phenobarbital]], especially in liver failure
	*[[Methylene blue]] for severe methemoglobinemia		*[[Methylene blue]] for severe methemoglobinemia
	*Folinic acid ([leucovorin]]) supplementation (hydrazines inhibit MTHF production)		*Folinic acid ([[leucovorin]]) supplementation (hydrazines inhibit MTHF production)
	*Liver transplant for refractory hepatic failure		*Liver transplant for refractory hepatic failure

Elcatracho: /* Background */

2021-02-06T01:18:18Z

Background

← Older revision		Revision as of 01:18, 6 February 2021
Line 4:		Line 4:
	*Fruit in the spring and early summer		*Fruit in the spring and early summer
	*Frequently mistaken for morel mushrooms<ref>Brozen R et al. Gyromitra Mushroom Toxicity. Apr 14, 2015. http://emedicine.medscape.com/article/817931-treatment#showall.</ref>		*Frequently mistaken for morel mushrooms<ref>Brozen R et al. Gyromitra Mushroom Toxicity. Apr 14, 2015. http://emedicine.medscape.com/article/817931-treatment#showall.</ref>
	*Inhibits formation of Vitamin B6 and GABA via hydrazine metabolite (similar to [[isoniazid toxicity]])		*Inhibits formation of Vitamin B6 and GABA via hydrazine metabolite (similar to [[INH toxicity\|isoniazid toxicity]])

	==Clinical Features==		==Clinical Features==

Elcatracho: /* Background */

2021-02-06T01:17:34Z

Background

← Older revision		Revision as of 01:17, 6 February 2021
Line 4:		Line 4:
	*Fruit in the spring and early summer		*Fruit in the spring and early summer
	*Frequently mistaken for morel mushrooms<ref>Brozen R et al. Gyromitra Mushroom Toxicity. Apr 14, 2015. http://emedicine.medscape.com/article/817931-treatment#showall.</ref>		*Frequently mistaken for morel mushrooms<ref>Brozen R et al. Gyromitra Mushroom Toxicity. Apr 14, 2015. http://emedicine.medscape.com/article/817931-treatment#showall.</ref>
	*Inhibits formation of Vitamin B6 and GABA via hydrazine metabolite		*Inhibits formation of Vitamin B6 and GABA via hydrazine metabolite (similar to [[isoniazid toxicity]])

	==Clinical Features==		==Clinical Features==

ClaireLewis: /* ManagementDiaz JH. Syndromic diagnosis and management of confirmed mushroom poisonings. Crit Care Med. 2005 Feb. 33(2):427-36. */

2019-01-30T15:55:51Z

ManagementDiaz JH. Syndromic diagnosis and management of confirmed mushroom poisonings. Crit Care Med. 2005 Feb. 33(2):427-36.

← Older revision		Revision as of 15:55, 30 January 2019
Line 37:		Line 37:
	*Avoid [[phenobarbital]], especially in liver failure		*Avoid [[phenobarbital]], especially in liver failure
	*[[Methylene blue]] for severe methemoglobinemia		*[[Methylene blue]] for severe methemoglobinemia
	*[~~[Folic acid~~]] supplementation (hydrazines inhibit MTHF production)		*Folinic acid ([leucovorin]]) supplementation (hydrazines inhibit MTHF production)
	*Liver transplant for refractory hepatic failure		*Liver transplant for refractory hepatic failure

ClaireLewis at 15:52, 30 January 2019

2019-01-30T15:52:02Z

← Older revision		Revision as of 15:52, 30 January 2019
Line 11:		Line 11:
	*[[Hypoglycemia]]		*[[Hypoglycemia]]
	*[[Rhabdomyolysis]]		*[[Rhabdomyolysis]]
	*Can present with refractory seizures due to GABA deficiency		*Can present with refractory [[seizures]] due to GABA deficiency
	*Hemolysis usually mild		*Hemolysis usually mild
	*Rarely methemoglobinemia		*Rarely [[methemoglobinemia]]

	==Differential Diagnosis==		==Differential Diagnosis==
Line 33:		Line 33:
	==Management<ref>Diaz JH. Syndromic diagnosis and management of confirmed mushroom poisonings. Crit Care Med. 2005 Feb. 33(2):427-36.</ref>==		==Management<ref>Diaz JH. Syndromic diagnosis and management of confirmed mushroom poisonings. Crit Care Med. 2005 Feb. 33(2):427-36.</ref>==
	*Supportive care		*Supportive care
	*Dextrose boluses/infusions		*[[Dextrose]] boluses/infusions
	*High dose pyridoxine for refractory seizures (5g IV initially) <ref> Berger KJ, Guss DA. Mycotoxins revisited: Part II. J Emerg Med. 2005;28(2):175. </ref>		*High dose [[pyridoxine]] for refractory seizures (5g IV initially) <ref> Berger KJ, Guss DA. Mycotoxins revisited: Part II. J Emerg Med. 2005;28(2):175. </ref>
	*Avoid phenobarbital, especially in liver failure		*Avoid [[phenobarbital]], especially in liver failure
	*Methylene blue for severe methemoglobinemia		*[[Methylene blue]] for severe methemoglobinemia
	*~~Folinic~~ acid supplementation (hydrazines inhibit MTHF production)		*[[Folic acid]] supplementation (hydrazines inhibit MTHF production)
	*Liver transplant for refractory hepatic failure		*Liver transplant for refractory hepatic failure

Rossdonaldson1: Text replacement - "Urinalysis" to "Urinalysis"

2018-10-20T23:13:56Z

Text replacement - "*Urinalysis" to "*Urinalysis"

← Older revision		Revision as of 23:13, 20 October 2018
Line 29:		Line 29:
	*MetHb level		*MetHb level
	*Urine drug screen		*Urine drug screen
	*Urinalysis		*[[Urinalysis]]

	==Management<ref>Diaz JH. Syndromic diagnosis and management of confirmed mushroom poisonings. Crit Care Med. 2005 Feb. 33(2):427-36.</ref>==		==Management<ref>Diaz JH. Syndromic diagnosis and management of confirmed mushroom poisonings. Crit Care Med. 2005 Feb. 33(2):427-36.</ref>==

Neil.m.young: Text replacement - "==Diagnosis==" to "==Evaluation=="

2016-07-22T08:42:28Z

Text replacement - "==Diagnosis==" to "==Evaluation=="

← Older revision		Revision as of 08:42, 22 July 2016
Line 18:		Line 18:
	{{Mushroom toxicity DDX}}		{{Mushroom toxicity DDX}}

	==~~Diagnosis~~==		==Evaluation==
	===Workup<ref>Tomková J, Ondra P, Válka I. Simultaneous determination of mushroom toxins α-amanitin, β-amanitin and muscarine in human urine by solid-phase extraction and ultra-high-performance liquid chromatography coupled with ultra-high-resolution TOF mass spectrometry. Forensic Sci Int. 2015 Jun. 251:209-13.</ref>===		===Workup<ref>Tomková J, Ondra P, Válka I. Simultaneous determination of mushroom toxins α-amanitin, β-amanitin and muscarine in human urine by solid-phase extraction and ultra-high-performance liquid chromatography coupled with ultra-high-resolution TOF mass spectrometry. Forensic Sci Int. 2015 Jun. 251:209-13.</ref>===
	*Blood sugar		*Blood sugar

Carpenj: /* ManagementDiaz JH. Syndromic diagnosis and management of confirmed mushroom poisonings. Crit Care Med. 2005 Feb. 33(2):427-36. */

2016-06-09T04:09:19Z

ManagementDiaz JH. Syndromic diagnosis and management of confirmed mushroom poisonings. Crit Care Med. 2005 Feb. 33(2):427-36.

← Older revision		Revision as of 04:09, 9 June 2016
Line 34:		Line 34:
	*Supportive care		*Supportive care
	*Dextrose boluses/infusions		*Dextrose boluses/infusions
	*High dose pyridoxine for refractory seizures (5g IV initially)		*High dose pyridoxine for refractory seizures (5g IV initially) <ref> Berger KJ, Guss DA. Mycotoxins revisited: Part II. J Emerg Med. 2005;28(2):175. </ref>
	*Avoid phenobarbital, especially in liver failure		*Avoid phenobarbital, especially in liver failure
	*Methylene blue for severe methemoglobinemia		*Methylene blue for severe methemoglobinemia

Rossdonaldson1 at 22:09, 11 May 2016

2016-05-11T22:09:46Z

← Older revision		Revision as of 22:09, 11 May 2016
Line 1:		Line 1:
			==Background==
	[[File:Gyromitra_mushrooms.jpg\|thumb\|Gyromitra mushrooms]]		[[File:Gyromitra_mushrooms.jpg\|thumb\|Gyromitra mushrooms]]
	~~==Overview==~~
	*Also known as "brain fungi"		*Also known as "brain fungi"
	*Fruit in the spring and early summer		*Fruit in the spring and early summer
Line 6:		Line 6:
	*Inhibits formation of Vitamin B6 and GABA via hydrazine metabolite		*Inhibits formation of Vitamin B6 and GABA via hydrazine metabolite

	==Clinical ~~findings~~==		==Clinical Features==
	*GI upset, fatigue, muscle cramps		*GI upset, fatigue, muscle cramps
	*Liver failure		*[[Liver failure]]
	*Hypoglycemia		*[[Hypoglycemia]]
	*Rhabdomyolysis		*[[Rhabdomyolysis]]
	*Can present with refractory seizures due to GABA deficiency		*Can present with refractory seizures due to GABA deficiency
	*Hemolysis usually mild		*Hemolysis usually mild
	*Rarely methemoglobinemia		*Rarely methemoglobinemia

	==Workup<ref>Tomková J, Ondra P, Válka I. Simultaneous determination of mushroom toxins α-amanitin, β-amanitin and muscarine in human urine by solid-phase extraction and ultra-high-performance liquid chromatography coupled with ultra-high-resolution TOF mass spectrometry. Forensic Sci Int. 2015 Jun. 251:209-13.</ref>==		==Differential Diagnosis==
			{{Mushroom toxicity DDX}}

			==Diagnosis==
			===Workup<ref>Tomková J, Ondra P, Válka I. Simultaneous determination of mushroom toxins α-amanitin, β-amanitin and muscarine in human urine by solid-phase extraction and ultra-high-performance liquid chromatography coupled with ultra-high-resolution TOF mass spectrometry. Forensic Sci Int. 2015 Jun. 251:209-13.</ref>===
	*Blood sugar		*Blood sugar
	*BMP		*BMP
Line 35:		Line 39:
	*Folinic acid supplementation (hydrazines inhibit MTHF production)		*Folinic acid supplementation (hydrazines inhibit MTHF production)
	*Liver transplant for refractory hepatic failure		*Liver transplant for refractory hepatic failure

			==Disposition==

	==See Also==		==See Also==

Kxl328 at 15:22, 11 May 2016

2016-05-11T15:22:51Z

← Older revision		Revision as of 15:22, 11 May 2016
Line 10:		Line 10:
	*Liver failure		*Liver failure
	*Hypoglycemia		*Hypoglycemia
			*Rhabdomyolysis
	*Can present with refractory seizures due to GABA deficiency		*Can present with refractory seizures due to GABA deficiency
	*Hemolysis usually mild		*Hemolysis usually mild

Gyromitra mushrooms - Revision history

ClaireLewis: /* ManagementDiaz JH. Syndromic diagnosis and management of confirmed mushroom poisonings. Crit Care Med. 2005 Feb. 33(2):427-36. */

Elcatracho: /* Background */

Elcatracho: /* Background */

ClaireLewis: /* ManagementDiaz JH. Syndromic diagnosis and management of confirmed mushroom poisonings. Crit Care Med. 2005 Feb. 33(2):427-36. */

ClaireLewis at 15:52, 30 January 2019

Rossdonaldson1: Text replacement - "*Urinalysis" to "*Urinalysis"

Neil.m.young: Text replacement - "==Diagnosis==" to "==Evaluation=="

Carpenj: /* ManagementDiaz JH. Syndromic diagnosis and management of confirmed mushroom poisonings. Crit Care Med. 2005 Feb. 33(2):427-36. */

Rossdonaldson1 at 22:09, 11 May 2016

Kxl328 at 15:22, 11 May 2016

Rossdonaldson1: Text replacement - "Urinalysis" to "Urinalysis"