https://wikem.org/w/index.php?action=history&feed=atom&title=Fluoxetine 2026-04-18T06:48:50Z Revision history for this page on the wiki MediaWiki 1.38.2 https://wikem.org/w/index.php?title=Fluoxetine&diff=229395&oldid=prev 2019-09-22T19:59:21Z

<p><span dir="auto"><span class="autocomment">References</span></span></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 19:59, 22 September 2019</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l124">Line 124:</td> <td colspan="2" class="diff-lineno">Line 124:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br/></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Pharmacology]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Pharmacology]]</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">[[Category:Psychiatry]]</ins></div></td></tr> </table>

ClaireLewis https://wikem.org/w/index.php?title=Fluoxetine&diff=162612&oldid=prev 2017-11-03T17:58:55Z

<p>Creation of page</p> <p><b>New page</b></p><div>==Administration==<br /> *Type: Antidepressant<br /> *Dosage Forms: 10mg, 20mg, 40mg<br /> *Routes of Administration: Oral<br /> *Common Trade Names: Prozac<br /> <br /> ==Adult Dosing==<br /> ===Major depressive disorder===<br /> *20-80mg PO qAM<br /> **Start 20mg PO qAM<br /> ===Obsessive-Compulsive Disorder===<br /> *20-60mg PO qAM<br /> **Start 20mg PO qAM<br /> ===[[Bulimia nervosa]]===<br /> *60mg PO qAM<br /> ===Panic Disorder===<br /> *20mg PO qAM<br /> ===[[Bipolar disorder]], Type I===<br /> *20-50mg PO qPM<br /> ===Cataplexy===<br /> *20-60mg PO qAM<br /> <br /> ==Pediatric Dosing==<br /> ===Major depressive disorder===<br /> *6-7 yo<br /> **10 mg PO qd<br /> *8-18 yo<br /> **10-20 mg PO qd<br /> ===Obsessive-Compulsive Disorder===<br /> *7-17 yo<br /> **20-60 mg PO qd<br /> ===[[Bipolar disorder]], type I===<br /> *10-17 yo<br /> **20-50 mg PO qd<br /> ===Bulimia nervosa===<br /> *12+ yo<br /> **20-60 mg PO qd<br /> ===Insomnia===<br /> *10-17 yo<br /> **10-20 mg PO qd<br /> ===PTSD===<br /> *7-17 yo<br /> **10-20 mg PO qd<br /> ===Social Anxiety Disorder===<br /> *5+ yo<br /> **20 mg PO qd<br /> ===Cataplexy===<br /> *5+ yo<br /> **10-40 mg PO qd<br /> <br /> ==Special Populations==<br /> *[[Drug pregnancy categories|Pregnancy Rating]]: C; Caution advised in 3rd trimester<br /> *Lactation risk: Consider alternative while breastfeeding<br /> ===Renal Dosing===<br /> *Adult:<br /> **No adjustment<br /> *Pediatric:<br /> **No adjustment<br /> ===Hepatic Dosing===<br /> *Adult:<br /> **Decrease dose or frequency<br /> *Pediatric:<br /> **Decrease dose or frequency<br /> <br /> ==Contraindications==<br /> *Allergy to class/drug<br /> *Caution:<br /> **Concurrent CNS depressant use<br /> **Alcohol use<br /> **Pts &lt; 25 yo<br /> **Elderly<br /> **Pregnancy 3rd trimester<br /> **Hepatic impairment<br /> **Poor CYP2D6 metabolizer<br /> **Bleeding risk<br /> **QT prolongation<br /> **CHF<br /> **Hypomania or mania history<br /> *Avoid abrupt withdrawal<br /> <br /> ==Adverse Reactions==<br /> ===Serious===<br /> *Suicidality<br /> *[[Depression]] exacerbation<br /> *Hypomania/mania<br /> *QT prolongation, [[torsades de pointes]]<br /> *[[Serotonin syndrome]]<br /> *[[Anaphylaxis]], [[Stevens-Johnson Syndrome]], Erythema multiforme<br /> *Serum sickness<br /> *[[Vasculitis]], Pulmonary fibrosis<br /> *[[Glaucoma]], angle-closure<br /> *[[Seizures]], [[Hyponatremia]], [[SIADH]]<br /> *[[Hypoglycemia]]<br /> *Priapism, Extrapyramidal symptoms<br /> <br /> ===Common===<br /> *Insomnia<br /> *[[Nausea]], [[vomiting]], [[diarrhea]]<br /> *[[Headache]], [[dizziness]]<br /> *Anorexia, anxiety, nervousness<br /> *Asthenia, somnolence<br /> *Sexual dysfunction<br /> *Dyspepsia<br /> *Abnormal dreams<br /> *[[Rash]]<br /> *Weight loss<br /> <br /> ==Pharmacology==<br /> *Half-life: 4-6 day (parent drug) and 9.3 days (active metabolite)<br /> *Metabolism: Liver, CYP2C19 and CYP2D6 (primary)<br /> *Excretion: Urine 80% (11.6% unchanged), Feces 15%<br /> <br /> ==Mechanism of Action==<br /> *Selectively inhibits serotonin reuptake<br /> <br /> ==Comments==<br /> <br /> <br /> ==See Also==<br /> <br /> <br /> ==References==<br /> &lt;references/&gt;<br /> <br /> [[Category:Pharmacology]]</div>

Jonwarren