Drug fever - Revision history

Rossdonaldson1 at 02:05, 27 November 2021

2021-11-27T02:05:27Z

← Older revision		Revision as of 02:05, 27 November 2021
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	==References==		==References==
	<references/>		<references/>

			[[Category:Toxicology]]

Rossdonaldson1: /* Pathophysiology */

2021-09-28T18:18:43Z

Pathophysiology

← Older revision		Revision as of 18:18, 28 September 2021
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	===Pathophysiology===		===Pathophysiology===
	Possible mechanisms:		Possible mechanisms:
	*~~hyper~~-metabolic state		*Hyper-metabolic state
	*Direct tissue damage and tissue necrosis		*Direct tissue damage and tissue necrosis
	*Interference with peripheral vasodilation		*Interference with peripheral vasodilation
	Activation of the cellular or humoral immune responses		*Activation of the cellular or humoral immune responses
	*Acting as an endogenous pyrogen.		*Acting as an endogenous pyrogen.

	==Clinical Features==		==Clinical Features==

Rossdonaldson1: /* Differential Diagnosis */

2021-09-28T18:17:56Z

Differential Diagnosis

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 ==Differential Diagnosis==
-===[[Fever]]===
+{{Acute Fever DDX}}
 ==Evaluation==

Rossdonaldson1 at 18:16, 28 September 2021

2021-09-28T18:16:18Z

← Older revision		Revision as of 18:16, 28 September 2021
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	*Also known as drug-induced hyperthermia		*Also known as drug-induced hyperthermia
	*An adverse reaction to a drug in which the recipient of the drug develops a fever		*An adverse reaction to a drug in which the recipient of the drug develops a fever
	**Most common classes ~~associated with drug fever~~ are antimicrobials, anticonvulsants, antidysrhythmics, and other cardiac agents<ref>Patel, R. A., & Gallagher, J. C. (2010). Drug Fever. Pharmacotherapy, 30(1), 57–69. doi:10.1592/phco.30.1.57</ref>		**Most common drug classes are antimicrobials, anticonvulsants, antidysrhythmics, and other cardiac agents<ref>Patel, R. A., & Gallagher, J. C. (2010). Drug Fever. Pharmacotherapy, 30(1), 57–69. doi:10.1592/phco.30.1.57</ref>

	===Pathophysiology===		===Pathophysiology===
	~~There are multiple~~ mechanisms ~~by which a drug can directly cause a fever response. These mechanisms include inducing a~~ hyper-metabolic state~~, direct~~ tissue damage and tissue necrosis~~, interference~~ with peripheral vasodilation~~, activation~~ of the cellular or humoral immune responses~~, or by acting~~ as an endogenous pyrogen. ~~<ref>Wikipedia, the Free Encyclopedia, "Drug-Induced hyperthermia" <https://en.wikipedia.org/wiki/Drug-induced_hyperthermia>, accessed 13 Jan 2021</ref>~~		Possible mechanisms:
			*hyper-metabolic state
			*Direct tissue damage and tissue necrosis
			*Interference with peripheral vasodilation
			Activation of the cellular or humoral immune responses
			*Acting as an endogenous pyrogen.

	==Clinical Features==		==Clinical Features==

Rossdonaldson1: /* Evaluation */

2021-09-28T18:14:30Z

Evaluation

← Older revision		Revision as of 18:14, 28 September 2021
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	==Evaluation==		==Evaluation==
			===Workup===
	*Thorough history and physical exam including review of medications		*Thorough history and physical exam including review of medications

	~~===Workup===~~

	===Diagnosis===		===Diagnosis===

Rossdonaldson1 at 18:09, 28 September 2021

2021-09-28T18:09:47Z

← Older revision		Revision as of 18:09, 28 September 2021
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	==Background==		==Background==
	~~Drug fever, or Drug~~-induced hyperthermia~~, is an~~ adverse reaction to a drug in which the recipient of the drug develops a fever ~~in direct response to receiving a specific~~ drug. There are multiple mechanisms by which a drug can directly cause a fever response. These mechanisms include inducing a hyper-metabolic state, direct tissue damage and tissue necrosis, interference with peripheral vasodilation, activation of the cellular or humoral immune responses, or by acting as an endogenous pyrogen. <ref>Wikipedia, the Free Encyclopedia, "Drug-Induced hyperthermia" <https://en.wikipedia.org/wiki/Drug-induced_hyperthermia>, accessed 13 Jan 2021~~</ref>~~		*Also known as drug-induced hyperthermia
	*Most common classes associated with drug fever are antimicrobials, anticonvulsants, antidysrhythmics, and other cardiac agents<ref>Patel, R. A., & Gallagher, J. C. (2010). Drug Fever. Pharmacotherapy, 30(1), 57–69. doi:10.1592/phco.30.1.57</ref>		*An adverse reaction to a drug in which the recipient of the drug develops a fever
			**Most common classes associated with drug fever are antimicrobials, anticonvulsants, antidysrhythmics, and other cardiac agents<ref>Patel, R. A., & Gallagher, J. C. (2010). Drug Fever. Pharmacotherapy, 30(1), 57–69. doi:10.1592/phco.30.1.57</ref>

			===Pathophysiology===
			There are multiple mechanisms by which a drug can directly cause a fever response. These mechanisms include inducing a hyper-metabolic state, direct tissue damage and tissue necrosis, interference with peripheral vasodilation, activation of the cellular or humoral immune responses, or by acting as an endogenous pyrogen. <ref>Wikipedia, the Free Encyclopedia, "Drug-Induced hyperthermia" <https://en.wikipedia.org/wiki/Drug-induced_hyperthermia>, accessed 13 Jan 2021</ref>

	==Clinical Features==		==Clinical Features==

Elcatracho: /* Evaluation */

2021-01-15T22:18:23Z

Evaluation

← Older revision		Revision as of 22:18, 15 January 2021
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	==Evaluation==		==Evaluation==
			*Thorough history and physical exam including review of medications

	===Workup===		===Workup===

Elcatracho: /* Background */

2021-01-15T22:06:15Z

Background

← Older revision		Revision as of 22:06, 15 January 2021
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	==Background==		==Background==
	Drug fever, or Drug-induced hyperthermia, is an adverse reaction to a drug in which the recipient of the drug develops a fever in direct response to receiving a specific drug. There are multiple mechanisms by which a drug can directly cause a fever response. These mechanisms include inducing a hyper-metabolic state, direct tissue damage and tissue necrosis, interference with peripheral vasodilation, activation of the cellular or humoral immune responses, or by acting as an endogenous pyrogen. <ref>Wikipedia, the Free Encyclopedia, "Drug-Induced hyperthermia" <https://en.wikipedia.org/wiki/Drug-induced_hyperthermia>, accessed 13 Jan 2021</ref>		Drug fever, or Drug-induced hyperthermia, is an adverse reaction to a drug in which the recipient of the drug develops a fever in direct response to receiving a specific drug. There are multiple mechanisms by which a drug can directly cause a fever response. These mechanisms include inducing a hyper-metabolic state, direct tissue damage and tissue necrosis, interference with peripheral vasodilation, activation of the cellular or humoral immune responses, or by acting as an endogenous pyrogen. <ref>Wikipedia, the Free Encyclopedia, "Drug-Induced hyperthermia" <https://en.wikipedia.org/wiki/Drug-induced_hyperthermia>, accessed 13 Jan 2021</ref>
			*Most common classes associated with drug fever are antimicrobials, anticonvulsants, antidysrhythmics, and other cardiac agents<ref>Patel, R. A., & Gallagher, J. C. (2010). Drug Fever. Pharmacotherapy, 30(1), 57–69. doi:10.1592/phco.30.1.57</ref>

	==Clinical Features==		==Clinical Features==

Elcatracho: /* Clinical Features */

2021-01-15T22:03:07Z

Clinical Features

← Older revision		Revision as of 22:03, 15 January 2021
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	==Clinical Features==		==Clinical Features==
	*Can occur at any point during therapy but most often occurs 7-10 days after initiation of drug<ref>Patel, R. A., & Gallagher, J. C. (2010). Drug Fever. Pharmacotherapy, 30(1), 57–69. doi:10.1592/phco.30.1.57</ref>		*Can occur at any point during therapy but most often occurs 7-10 days after initiation of drug<ref>Patel, R. A., & Gallagher, J. C. (2010). Drug Fever. Pharmacotherapy, 30(1), 57–69. doi:10.1592/phco.30.1.57</ref>
			*May appear "inappropriately well" for the degree of fever

	==Differential Diagnosis==		==Differential Diagnosis==

Elcatracho: /* Clinical Features */

2021-01-15T22:02:13Z

Clinical Features

← Older revision		Revision as of 22:02, 15 January 2021
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	==Clinical Features==		==Clinical Features==
			*Can occur at any point during therapy but most often occurs 7-10 days after initiation of drug<ref>Patel, R. A., & Gallagher, J. C. (2010). Drug Fever. Pharmacotherapy, 30(1), 57–69. doi:10.1592/phco.30.1.57</ref>

	==Differential Diagnosis==		==Differential Diagnosis==