Diethylcarbamazine - Revision history

Ostermayer: /* Lymphatic filariasis */

2022-04-03T13:14:20Z

Lymphatic filariasis

← Older revision		Revision as of 13:14, 3 April 2022
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	==Adult Dosing==		==Adult Dosing==
	===[[Lymphatic filariasis]]===		===[[Lymphatic filariasis]]===
	*''including lymphatic filariasis caused by infection with Wuchereria bancrofti, Brugia malayi, or Brugia timori''		*''including lymphatic filariasis caused by infection with [[Wuchereria bancrofti]], [[Brugia malayi]], or [[Brugia timori]]''
	{{Filariasis dec treatment}}		{{Filariasis dec treatment}}

Ostermayer: /* Adult Dosing */

2022-04-03T13:13:49Z

Adult Dosing

← Older revision		Revision as of 13:13, 3 April 2022
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	==Adult Dosing==		==Adult Dosing==
	[[Lymphatic filariasis]]		===[[Lymphatic filariasis]]===
	*''including lymphatic filariasis caused by infection with Wuchereria bancrofti, Brugia malayi, or Brugia timori''		*''including lymphatic filariasis caused by infection with Wuchereria bancrofti, Brugia malayi, or Brugia timori''
	{{Filariasis dec treatment}}		{{Filariasis dec treatment}}

	[[Loa Loa]]		===[[Loa Loa]]===
	{{loa loa dec treatment}}		{{loa loa dec treatment}}
	[[Mansonella streptocerca]]		===[[Mansonella streptocerca]]===
	*6 mg/kg PO qDay x14 days		*6 mg/kg PO qDay x14 days

Ostermayer: /* Adult Dosing */

2022-04-03T13:09:10Z

Adult Dosing

← Older revision		Revision as of 13:09, 3 April 2022
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	[[Loa Loa]]		[[Loa Loa]]
	*Day 1: 50 mg PO PC		{{loa loa dec treatment}}
	*Day 2: 50 mg PO TID
	*Day 3: 100 mg PO TID
	*Day 4-21: 9 mg/kg/day PO divided TID

	[[Mansonella streptocerca]]		[[Mansonella streptocerca]]
	*6 mg/kg PO qDay x14 days		*6 mg/kg PO qDay x14 days

Ostermayer: /* Adult Dosing */

2022-04-03T13:08:36Z

Adult Dosing

← Older revision		Revision as of 13:08, 3 April 2022
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	[[Lymphatic filariasis]]		[[Lymphatic filariasis]]
	*''including lymphatic filariasis caused by infection with Wuchereria bancrofti, Brugia malayi, or Brugia timori''		*''including lymphatic filariasis caused by infection with Wuchereria bancrofti, Brugia malayi, or Brugia timori''
	*Day 1: 50 mg PO PC		{{Filariasis dec treatment}}
	*Day 2: 50 mg PO TID
	*Day 3: 100 mg PO TID
	*Day 4-14: 6 mg/kg/day PO divided TID

	[[Loa Loa]]		[[Loa Loa]]
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	[[Mansonella streptocerca]]		[[Mansonella streptocerca]]
	*6 mg/kg PO qDay x14 days		*6 mg/kg PO qDay x14 days

	==Pediatric Dosing==		==Pediatric Dosing==
	*Day 1: 1 mg/kg orally after meals		*Day 1: 1 mg/kg orally after meals

Ostermayer: /* Adverse Reactions */

2022-04-03T13:06:55Z

Adverse Reactions

← Older revision		Revision as of 13:06, 3 April 2022
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	==Adverse Reactions==		==Adverse Reactions==
	===Serious===		===Serious===
			*Anaphylaxis if allergic to Hetrazan

	===Common===		===Common===
			*Fever
			*GI distress

	==Pharmacology==		==Pharmacology==

Ostermayer: /* Pregnancy Rating */

2022-04-03T13:05:45Z

Pregnancy Rating

← Older revision		Revision as of 13:05, 3 April 2022
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	==Special Populations==		==Special Populations==
	===[[Drug pregnancy categories\|Pregnancy Rating]]===		===[[Drug pregnancy categories\|Pregnancy Rating]]===
	*		*Do not use diethylcarbamazine in pregnancy.

	===Lactation risk===		===Lactation risk===

Ostermayer at 13:03, 3 April 2022

2022-04-03T13:03:47Z

← Older revision		Revision as of 13:03, 3 April 2022
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	==Administration==		==Administration==
	*Mechanism of Action: interferes with cyclooxygenase and lipoxygenase pathways, reducing the production of thromboxane, prostacyclin, prostaglandin and leukotrienes		*Mechanism of Action: interferes with cyclooxygenase and lipoxygenase pathways, reducing the production of thromboxane, prostacyclin, prostaglandin and leukotrienes
	*Dosage Forms:		*Dosage Forms: tablets
	*Routes of Administration:		*Routes of Administration: oral
	*Common Trade Names:		*Common Trade Names: N/A

	==Adult Dosing==		==Adult Dosing==
			[[Lymphatic filariasis]]
			*''including lymphatic filariasis caused by infection with Wuchereria bancrofti, Brugia malayi, or Brugia timori''
			*Day 1: 50 mg PO PC
			*Day 2: 50 mg PO TID
			*Day 3: 100 mg PO TID
			*Day 4-14: 6 mg/kg/day PO divided TID

			[[Loa Loa]]
			*Day 1: 50 mg PO PC
			*Day 2: 50 mg PO TID
			*Day 3: 100 mg PO TID
			*Day 4-21: 9 mg/kg/day PO divided TID

			[[Mansonella streptocerca]]
			*6 mg/kg PO qDay x14 days
	==Pediatric Dosing==		==Pediatric Dosing==
			*Day 1: 1 mg/kg orally after meals
			*Day 2: 1 mg/kg orally three times daily
			*Day 3: 1-2 mg/kg orally three times daily
			*Day 4-14: 6 mg/kg/day orally divided three times daily

	==Special Populations==		==Special Populations==
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	==Pharmacology==		==Pharmacology==
	*Half-life:		*Half-life: 8hrs
	*Metabolism:		*Metabolism: Partially metabolized to diethylcarbamazine N-oxide.
	*Excretion:		*Excretion:

Ostermayer: /* Overview */

2022-04-03T12:51:39Z

Overview

← Older revision		Revision as of 12:51, 3 April 2022
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	==Overview==		==Overview==
	Diethylcarbamazine (DEC) used globally its anti-filaricidal activity<ref>Peixoto CA et al. Anti-inflammatory effects of diethylcarbamazine: A review. European Journal of Pharmacology 734 (2014) 35–41</ref>		Diethylcarbamazine (DEC) used globally its anti-filaricidal activity<ref>Peixoto CA et al. Anti-inflammatory effects of diethylcarbamazine: A review. European Journal of Pharmacology 734 (2014) 35–41</ref>

	==Administration==		==Administration==
	*Mechanism of Action: interferes with cyclooxygenase and lipoxygenase pathways, reducing the production of thromboxane, prostacyclin, prostaglandin and leukotrienes		*Mechanism of Action: interferes with cyclooxygenase and lipoxygenase pathways, reducing the production of thromboxane, prostacyclin, prostaglandin and leukotrienes

Ostermayer at 12:44, 3 April 2022

2022-04-03T12:44:03Z

← Older revision		Revision as of 12:44, 3 April 2022
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	==Overview==		==Overview==
	Diethylcarbamazine (DEC) used ~~as a key medication for~~ its anti-filaricidal activity<ref>Peixoto CA et al. Anti-inflammatory effects of diethylcarbamazine: A review. European Journal of Pharmacology 734 (2014) 35–41</ref>		Diethylcarbamazine (DEC) used globally its anti-filaricidal activity<ref>Peixoto CA et al. Anti-inflammatory effects of diethylcarbamazine: A review. European Journal of Pharmacology 734 (2014) 35–41</ref>
	==Administration==		==Administration==
	*Mechanism of Action: interferes with cyclooxygenase and lipoxygenase pathways, reducing the production of thromboxane, prostacyclin, prostaglandin and leukotrienes		*Mechanism of Action: interferes with cyclooxygenase and lipoxygenase pathways, reducing the production of thromboxane, prostacyclin, prostaglandin and leukotrienes

Ostermayer: Created page with "==Overview== Diethylcarbamazine (DEC) used as a key medication for its anti-filaricidal activityPeixoto CA et al. Anti-inflammatory effects of diethylcarbamazine: A revie..."

2022-04-03T12:43:40Z

Created page with "==Overview== Diethylcarbamazine (DEC) used as a key medication for its anti-filaricidal activity<ref>Peixoto CA et al. Anti-inflammatory effects of diethylcarbamazine: A revie..."

New page

==Overview==
Diethylcarbamazine (DEC) used as a key medication for its anti-filaricidal activity<ref>Peixoto CA et al. Anti-inflammatory effects of diethylcarbamazine: A review. European Journal of Pharmacology 734 (2014) 35–41</ref>
==Administration==
*Mechanism of Action: interferes with cyclooxygenase and lipoxygenase pathways, reducing the production of thromboxane, prostacyclin, prostaglandin and leukotrienes
*Dosage Forms:
*Routes of Administration:
*Common Trade Names:

==Adult Dosing==

==Pediatric Dosing==

==Special Populations==
===[[Drug pregnancy categories|Pregnancy Rating]]===
*

===Lactation risk===
*

===Renal Dosing===
*Adult:
*Pediatric:

===Hepatic Dosing===
*Adult:
*Pediatric:

==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
===Serious===

===Common===

==Pharmacology==
*Half-life:
*Metabolism:
*Excretion:

==Mechanism of Action==

==Comments==

==See Also==
*[[Ivermectin]]
*[[Albendazole]]
*[[Loa Loa]]
*[[Lymphatic filariasis]]

==References==
<references/>

[[Category:Pharmacology]]