Clenbuterol toxicity - Revision history

Rossdonaldson1: Text replacement - "Poison Control Center" to "poison control"

2018-08-13T19:31:15Z

Text replacement - "Poison Control Center" to "poison control"

← Older revision		Revision as of 19:31, 13 August 2018
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	*Most patients require admission due to the long half life of clenbuterol		*Most patients require admission due to the long half life of clenbuterol
	*Patients with severe symptoms or those with myocardial ischemia should be admitted for continued monitoring and appropriated cardiac managment<ref>Werder G. et al. Clenbuterol-contaminated heroin: Cardiovascular and metabolic effects. A case series and review. Conn Med. 2006; 70(1):5-11</ref>		*Patients with severe symptoms or those with myocardial ischemia should be admitted for continued monitoring and appropriated cardiac managment<ref>Werder G. et al. Clenbuterol-contaminated heroin: Cardiovascular and metabolic effects. A case series and review. Conn Med. 2006; 70(1):5-11</ref>
	*Contact ~~Poison Control Center~~		*Contact [[poison control]]

	==See Also==		==See Also==

Neil.m.young: Text replacement - "beta blocker" to "β-blocker"

2017-07-26T19:07:01Z

Text replacement - "beta blocker" to "β-blocker"

← Older revision		Revision as of 19:07, 26 July 2017
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	*In an isolated severe overdose without associated cocaine igestions, β-blockade can be given via IV metoprolol, labetolol or esmolol		*In an isolated severe overdose without associated cocaine igestions, β-blockade can be given via IV metoprolol, labetolol or esmolol
	*Beta blockade may reverse the associated hypotension from the excessive Beta agonism of the clenbuterol<ref name="Barry">Barry AR, Graham MM. Case report and review of clenbuterol cardiac toxicity .J Cardiol Cases. 2013;8:131-133</ref>		*Beta blockade may reverse the associated hypotension from the excessive Beta agonism of the clenbuterol<ref name="Barry">Barry AR, Graham MM. Case report and review of clenbuterol cardiac toxicity .J Cardiol Cases. 2013;8:131-133</ref>
	**Do not administer ~~beta~~ blocker if there is a chance of associated cocaine use. Diltiazem is an alternative for these situations<ref name="Barry"></ref>		**Do not administer β-blocker if there is a chance of associated cocaine use. Diltiazem is an alternative for these situations<ref name="Barry"></ref>

	==Disposition==		==Disposition==

Rossdonaldson1: Text replacement - "Chest pain" to "Chest pain"

2016-09-25T22:25:58Z

Text replacement - "*Chest pain" to "*Chest pain"

← Older revision		Revision as of 22:25, 25 September 2016
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	*Nausea		*Nausea
	*Palpitations		*Palpitations
	*Chest pain		*[[Chest pain]]
	*Dyspnea		*Dyspnea
	*Tachycardia		*Tachycardia

Neil.m.young: Text replacement - "==Diagnosis==" to "==Evaluation=="

2016-07-21T19:14:22Z

Text replacement - "==Diagnosis==" to "==Evaluation=="

← Older revision		Revision as of 19:14, 21 July 2016
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	{{Toxidrome Chart}}		{{Toxidrome Chart}}
	==~~Diagnosis~~==		==Evaluation==
	Lab testing may show:		Lab testing may show:
	*Hyperglycemia		*Hyperglycemia

Ostermayer: Text replacement - "Category:Tox" to "Category:Toxicology"

2016-03-22T16:22:46Z

Text replacement - "Category:Tox" to "Category:Toxicology"

← Older revision		Revision as of 16:22, 22 March 2016
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	==References==		==References==
	<references/>		<references/>
	[[Category:~~Tox~~]]		[[Category:Toxicology]]

Rossdonaldson1: Rossdonaldson1 moved page Clenbuterol to Clenbuterol toxicity

2015-10-25T08:36:59Z

Rossdonaldson1 moved page Clenbuterol to Clenbuterol toxicity

← Older revision	Revision as of 08:36, 25 October 2015
(No difference)

Ostermayer: /* Background */

2015-10-23T18:54:53Z

Background

← Older revision		Revision as of 18:54, 23 October 2015
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	''This page refers to Clenbuterol overdose not dosing of Clenbuterol''		''This page refers to Clenbuterol overdose not dosing of Clenbuterol''
	==Background==		==Background==
	Clenbuterol is found as an adulterant in both cocain and heroin. There have been many reports of clenbuterol overdoses and outbreaks.<ref> CDC. Atypical reactions associated with heroin use - five states, Jan-April 2015. MMWR. 20025;54(32):793-796</ref> It is a long acting B2-agonist used internationally and within the US mainly in veterinary medicine as bronochodilator. In addition to being added into heroin it is also used to increase lean mass of livestock and in racehorses<ref>Hoffman RS, Kirrane BM, et al. A descriptive study of an outbreak of clenbuterol-containing heroin. Ann Emerg Med. 2008;52(5):548-553</ref>		*Clenbuterol is found as an adulterant in both cocain and heroin. There have been many reports of clenbuterol overdoses and outbreaks.<ref> CDC. Atypical reactions associated with heroin use - five states, Jan-April 2015. MMWR. 20025;54(32):793-796</ref> It is a long acting B2-agonist used internationally and within the US mainly in veterinary medicine as bronochodilator. In addition to being added into heroin it is also used to increase lean mass of livestock and in racehorses<ref>Hoffman RS, Kirrane BM, et al. A descriptive study of an outbreak of clenbuterol-containing heroin. Ann Emerg Med. 2008;52(5):548-553</ref>
			*Athletes and body builders also abuse clenbuterol in order to increase muscle mass and decrease body fat.
			*Street Name: Clen
			*Formulation: Tablet or syrup
			*Half Life: 25-39 hrs

	==Clinical Features==		==Clinical Features==
	*Nausea		*Nausea

Ostermayer: /* Disposition */

2015-10-23T18:52:38Z

Disposition

← Older revision		Revision as of 18:52, 23 October 2015
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	==Disposition==		==Disposition==
			*Most patients require admission due to the long half life of clenbuterol
	*Patients with severe symptoms or those with myocardial ischemia should be admitted for continued monitoring and appropriated cardiac managment<ref>Werder G. et al. Clenbuterol-contaminated heroin: Cardiovascular and metabolic effects. A case series and review. Conn Med. 2006; 70(1):5-11</ref>		*Patients with severe symptoms or those with myocardial ischemia should be admitted for continued monitoring and appropriated cardiac managment<ref>Werder G. et al. Clenbuterol-contaminated heroin: Cardiovascular and metabolic effects. A case series and review. Conn Med. 2006; 70(1):5-11</ref>
	*Contact Poison Control Center		*Contact Poison Control Center

	==See Also==		==See Also==
	*[[Rhabdomyolysis]]		*[[Rhabdomyolysis]]

Ostermayer: /* Severe Overdoses */

2015-10-23T18:51:56Z

Severe Overdoses

← Older revision		Revision as of 18:51, 23 October 2015
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	===Severe Overdoses===		===Severe Overdoses===
	*In an isolated severe overdose without associated cocaine igestions, β-blockade can be given via IV metoprolol, labetolol or esmolol		*In an isolated severe overdose without associated cocaine igestions, β-blockade can be given via IV metoprolol, labetolol or esmolol
	*Beta blockade may reverse the associated hypotension from the excessive Beta agonism of the clenbuterol<ref>Barry AR, Graham MM. Case report and review of clenbuterol cardiac toxicity .J Cardiol Cases. 2013;8:131-133</ref>		*Beta blockade may reverse the associated hypotension from the excessive Beta agonism of the clenbuterol<ref name="Barry">Barry AR, Graham MM. Case report and review of clenbuterol cardiac toxicity .J Cardiol Cases. 2013;8:131-133</ref>
	**Do not administer beta blocker if there is a chance of associated cocaine use.		**Do not administer beta blocker if there is a chance of associated cocaine use. Diltiazem is an alternative for these situations<ref name="Barry"></ref>

	==Disposition==		==Disposition==
	*Patients with severe symptoms or those with myocardial ischemia should be admitted for continued monitoring and appropriated cardiac managment<ref>Werder G. et al. Clenbuterol-contaminated heroin: Cardiovascular and metabolic effects. A case series and review. Conn Med. 2006; 70(1):5-11</ref>		*Patients with severe symptoms or those with myocardial ischemia should be admitted for continued monitoring and appropriated cardiac managment<ref>Werder G. et al. Clenbuterol-contaminated heroin: Cardiovascular and metabolic effects. A case series and review. Conn Med. 2006; 70(1):5-11</ref>

Ostermayer at 18:47, 23 October 2015

2015-10-23T18:47:57Z

← Older revision		Revision as of 18:47, 23 October 2015
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	==References==		==References==
	<references/>		<references/>
			[[Category:Tox]]