Ostermayer at 20:21, 28 January 2026

2026-01-28T20:21:11Z

Ostermayer: Created page with " This is an example wiki page for the This is an emergency medicine antibiotic wiki example page that is on the wiki wikem.org ==General== Type: Is Generation::1st generation Is DrugClass::Cephalosporin Dosage Forms: powder for injection Dosage Strengths: 500mg; 1, 2, 10, 20, 100, 300g Routes of Administration: IV, IM Common Trade Names: Ancef ==Adult Dosing== ===General=== Mild: 250-500mg IM/IV 8h Mod-Severe: 500-1000mg IM/IV q6-8h Life Threatening:..."

2026-01-28T20:20:47Z

Created page with " This is an example wiki page for the This is an emergency medicine antibiotic wiki example page that is on the wiki wikem.org ==General== *Type: Is Generation::1st generation Is DrugClass::Cephalosporin *Dosage Forms: powder for injection *Dosage Strengths: 500mg; 1, 2, 10, 20, 100, 300g *Routes of Administration: IV, IM *Common Trade Names: Ancef ==Adult Dosing== ===General=== *Mild: 250-500mg IM/IV 8h *Mod-Severe: 500-1000mg IM/IV q6-8h *Life Threatening:..."

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This is an example wiki page for the

This is an emergency medicine antibiotic wiki example page that is on the wiki wikem.org

==General==
*Type: [[Is Generation::1st generation]] [[Is DrugClass::Cephalosporin]]
*Dosage Forms: powder for injection
*Dosage Strengths: 500mg; 1, 2, 10, 20, 100, 300g
*Routes of Administration: IV, IM
*Common Trade Names: Ancef

==Adult Dosing==
===General===
*Mild: 250-500mg IM/IV 8h
*Mod-Severe: 500-1000mg IM/IV q6-8h
*Life Threatening: 1-1.5g IM/IV q6h
*Max: 12g/day

===[[UTI]], Uncomplicated===
*1g IM/IV q12

===Pneumococcal [[Pneumonia]]===
*500mg IM/IV q12

===[[Endocarditis]] Prophylaxis, Dental===
*1g IM/IV x1 (30-60 min before procedure)

==Pediatric Dosing==
===General (<7 Days)===
*40mg/kg/day IM/IV divided q12h
*First Dose: 20mg/kg IM/IV x 1
*Max 6g/day

===General (>7 Days - 1 Month)===
*<2000g
**40mg/kg/day IM/IV divided q12h
**First Dose: 20mg/kg IM/IV x 1
**Max 6g/day
*>2000g
**60mg/kg/day IM/IV divided q8h
**First Dose: 20mg/kg IM/IV x 1
**Max 6g/day

===General (>1 Month)===
*25-100mg/kg/day IM/IV divided q6-8h
*First Dose: 20-33mg/kg IM/IV x 1
*Max 6g/day

===Community Acquired [[Pneumonia]] (>3 Months)===
*150mg/kg/day IM/IV divided q8h x 10 days
*First Dose: 50mg/kg IM/IV x 1
*May switch to PO regimen when able

==Special Populations==
*Pregnancy: B
*Lactation: Safe
*Renal
**Adult
***CrCl 35-54: give q8
***CrCl 11-34: give usual dose x1, then decrease dose 50% and give q12h
***CrCl <10: give usual dose x1, then decrease dose 50% and give q18-24h
***Hemodialysis: give 0.5-1g supplement
***Peritoneal dialysis: 500mg q12h
**Pediatric
***CrCl 40-70: give usual dose x 1, then decrease daily dose 40% and give q12h
***CrCl 20-39: give usual dose x 1, then decrease daily dose 75% and give q12h
***CrCl 5-19: give usual dose x 1, the decerase daily dose 90% and give q24h
***CrCl <5: not defined
***Hemodialysis: give supplement
***Peritoneal dialysis: no supplement
*Hepatic (Adult & Pediatric)
**Not defined

==Contraindications==
*Allergy to class/drug

==Adverse Reactions==
===Serious===
*Neutropenia
*[[Thrombocytopenia]]
*[[Anaphylaxis]]
*[[Stevens-Johnson Syndrome]]
*Nephrotoxicity
*[[Seizures]]
*[[Clostridium difficile]]

===Common===
*[[Diarrhea]]
*[[Rash]]
*[[Nausea and Vomiting]]
*[[Abdominal Pain]]
*Anorexia
*Transaminitis
*Urticaria
*Thrombophlebitis

==Pharmacology==
*Half-life: 1.8h (3.7 ESRD)
*Metabolism: minimally metabolized in liver; CYP450
*Excretion: Urine
*Mechanism of Action: Bactericidal; inhibits cell wall mucopeptide synthesis

==[[Antibiotic Sensitivities]]<ref>Sanford Guide to Antimicrobial Therapy 2014</ref>==
{| class="wikitable"
| align="center" style="background:#f0f0f0;"|'''Group'''
| align="center" style="background:#f0f0f0;"|'''Organism'''
| align="center" style="background:#f0f0f0;"|'''Sensitivity'''
|-
| Gram Positive||[[Strep. Group A, B, C, G]]||'''S'''
|-
| ||[[Strep. Pneumoniae]]||'''S'''
|-
| ||[[Viridans strep]]||'''S'''
|-
| ||Strep. anginosus gp||X1
|-
| ||[[Enterococcus faecalis]]||R
|-
| ||[[Enterococcus faecium]]||X1
|-
| ||[[MSSA]]||'''S'''
|-
| ||[[MRSA]]||R
|-
| ||[[CA-MRSA]]||R
|-
| ||[[Staph. Epidermidis]]||I
|-
| ||[[C. jeikeium]]||R
|-
| ||[[L. monocytogenes]]||R
|-
| Gram Negatives||[[N. gonorrhoeae]]||'''S'''
|-
| ||[[N. meningitidis]]||R
|-
| ||[[Moraxella catarrhalis]]||I
|-
| ||[[H. influenzae]]||'''S'''
|-
| ||[[E. coli]]||'''S'''
|-
| ||[[Klebsiella]] sp||'''S'''
|-
| ||E. coli/Klebsiella ESBL+||R
|-
| ||E coli/Klebsiella KPC+||R
|-
| ||[[Enterobacter]] sp, AmpC neg||R
|-
| ||[[Enterobacter]] sp, AmpC pos||R
|-
| ||[[Serratia]] sp||R
|-
| ||Serratia marcescens||X1
|-
| ||[[Salmonella]] sp||X1
|-
| ||[[Shigella]] sp||X1
|-
| ||[[Proteus mirabilis]]||'''S'''
|-
| ||[[Proteus vulgaris]]||R
|-
| ||[[Providencia sp.]]||R
|-
| ||[[Morganella sp.]]||R
|-
| ||[[Citrobacter freundii]]||R
|-
| ||[[Citrobacter diversus]]||R
|-
| ||[[Citrobacter sp.]]||R
|-
| ||[[Aeromonas sp]]||R
|-
| ||[[Acinetobacter sp.]]||R
|-
| ||[[Pseudomonas aeruginosa]]||R
|-
| ||[[Burkholderia cepacia]]||R
|-
| ||[[Stenotrophomonas maltophilia]]||R
|-
| ||[[Yersinia enterocolitica]]||R
|-
| ||[[Francisella tularensis]]||X1
|-
| ||[[Brucella sp.]]||X1
|-
| ||[[Legionella sp.]]||R
|-
| ||[[Pasteurella multocida]]||X1
|-
| ||[[Haemophilus ducreyi]]||X1
|-
| ||[[Vibrio vulnificus]]||X1
|-
| Misc||[[Chlamydophila sp]]||X1
|-
| ||[[Mycoplasm pneumoniae]]||X1
|-
| ||[[Rickettsia sp]]||X1
|-
| ||[[Mycobacterium avium]]||X1
|-
| Anaerobes||[[Actinomyces]]||X1
|-
| ||[[Bacteroides fragilis]]||R
|-
| ||[[Prevotella melaninogenica]]||X1
|-
| ||[[Clostridium difficile]]||X1
|-
| ||[[Clostridium (not difficile)]]||X1
|-
| ||[[Fusobacterium necrophorum]]||X1
|-
| ||[[Peptostreptococcus sp.]]||X1
|}

===Key===
{{Template:Antibacterial Spectra Key}}

==See Also==
*[[Antibiotics (Main)]]

==References==
<references/>
*Epocrates

[[Category:Pharmacology]] [[Category:ID]]

please create a new wiki page formatted in the same way as the wikitext in the example but for this antibiotic Ceftobiprole and don't forget to put the [[Category:Pharmacology]] [[Category:ID]] at the end. Make sure you use the semantic mediawiki text for the cephalosporin type such as *Type: [[Is Generation::1st generation]] [[Is DrugClass::Cephalosporin]] if it applies. If it is sensitive to pseudomonus make sure it has '''[[Has Antipseudomonal::S]]'''

Ceftobiprole - Revision history

Ostermayer at 20:21, 28 January 2026