Ostermayer: Created page with "==General== *Type: Is Generation::2nd generation Is DrugClass::Cephalosporin **Technically a Cephamycin antibotic Dosage Forms: powder for injection Dosage Strengths: 500mg, 1g Routes of Administration: IV, IM Common Trade Names: Tomiporan, Keiperazon ==Adult Dosing== ===General=== 1g IM/IV q12h Max: 4g/day ===Severe Infection/Sepsis=== 2g IM/IV q12h ===Pre-operative Prophylaxis=== 1g IM/IV x1 (30-60 min before procedure) ==Pediatric Dosing== ===Gener..."

2026-01-27T17:55:30Z

Created page with "==General== *Type: Is Generation::2nd generation Is DrugClass::Cephalosporin **Technically a Cephamycin antibotic *Dosage Forms: powder for injection *Dosage Strengths: 500mg, 1g *Routes of Administration: IV, IM *Common Trade Names: Tomiporan, Keiperazon ==Adult Dosing== ===General=== *1g IM/IV q12h *Max: 4g/day ===Severe Infection/Sepsis=== *2g IM/IV q12h ===Pre-operative Prophylaxis=== *1g IM/IV x1 (30-60 min before procedure) ==Pediatric Dosing== ===Gener..."

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==General==
*Type: [[Is Generation::2nd generation]] [[Is DrugClass::Cephalosporin]]
**Technically a Cephamycin antibotic
*Dosage Forms: powder for injection
*Dosage Strengths: 500mg, 1g
*Routes of Administration: IV, IM
*Common Trade Names: Tomiporan, Keiperazon

==Adult Dosing==
===General===
*1g IM/IV q12h
*Max: 4g/day

===Severe Infection/Sepsis===
*2g IM/IV q12h

===Pre-operative Prophylaxis===
*1g IM/IV x1 (30-60 min before procedure)

==Pediatric Dosing==
===General===
*30-50mg/kg/day IM/IV divided q12h
*Max: 2g/day

===Severe Infection===
*Up to 100mg/kg/day IM/IV divided q12h

==Special Populations==
*Pregnancy: Not formally categorized (FDA); presumed similar to other cephalosporins (Use if benefit outweighs risk)
*Lactation: Excreted in breast milk; caution advised
*Renal
**Adult
***CrCl >50: No adjustment
***CrCl 25-50: 500mg q12h or 1g q24h
***CrCl <25: 500mg q24-48h
**Pediatric
***Renal impairment guidelines not well defined; decrease dose/frequency proportional to adult reduction
*Hepatic
**No adjustment usually necessary; monitor INR due to N-MTT side chain risks

==Contraindications==
*Allergy to class/drug
*History of alcohol use (due to Disulfiram-like reaction)

==Adverse Reactions==
===Serious===
*[[Anaphylaxis]]
* Hypoprothrombinemia (Bleeding risk) due to N-methylthiotetrazole (NMTT) side chain (Check INR/PT)
*[[Stevens-Johnson Syndrome]]
*[[Pseudomembranous colitis]] ([[Clostridium difficile]])
*Disulfiram-like reaction with alcohol intake

===Common===
*[[Diarrhea]]
*[[Rash]] (Maculopapular)
*[[Nausea and Vomiting]]
*Injection site pain
*Eosinophilia

==Pharmacology==
*Half-life: 1.6 - 2.0h
*Metabolism: Not actively metabolized
*Excretion: Urine (unchanged)
*Mechanism of Action: Bactericidal; inhibits cell wall mucopeptide synthesis.
**Note: As a cephamycin, it has a 7-alpha-methoxy group providing high stability against beta-lactamases.

==[[Antibiotic Sensitivities]]==
{| class="wikitable"
| align="center" style="background:#f0f0f0;"|'''Group'''
| align="center" style="background:#f0f0f0;"|'''Organism'''
| align="center" style="background:#f0f0f0;"|'''Sensitivity'''
|-
| Gram Positive||[[Strep. Group A, B, C, G]]||'''S'''
|-
| ||[[Strep. Pneumoniae]]||'''S'''
|-
| ||[[Enterococcus faecalis]]||R
|-
| ||[[MSSA]]||'''S'''
|-
| ||[[MRSA]]||R
|-
| Gram Negatives||[[N. gonorrhoeae]]||'''S'''
|-
| ||[[E. coli]]||'''S'''
|-
| ||[[Klebsiella]] sp||'''S'''
|-
| ||[[Indole-positive Proteus]]||'''S'''
|-
| ||[[Serratia]] sp||I
|-
| ||[[Pseudomonas aeruginosa]]||I/R
|-
| Anaerobes||[[Bacteroides fragilis]]||'''S'''
|-
| ||[[Clostridium difficile]]||X1
|}

===Key===
{{Template:Antibacterial Spectra Key}}

==See Also==
*[[Antibiotics (Main)]]
*[[Cephalosporins]]

==References==
<references/>

[[Category:Pharmacology]] [[Category:ID]]

Cefbuperazone - Revision history