https://wikem.org/w/index.php?action=history&feed=atom&title=Calcium_disodium_EDTA 2026-04-18T11:01:29Z Revision history for this page on the wiki MediaWiki 1.38.2 https://wikem.org/w/index.php?title=Calcium_disodium_EDTA&diff=389792&oldid=prev 2026-03-25T02:59:31Z

<p>Created Calcium disodium EDTA (CaNa2EDTA) medication page for lead chelation with standard template</p> <p><b>New page</b></p><div>==Administration==<br /> *Type: Chelating agent<br /> *Dosage Forms: injection (200 mg/mL)<br /> *Routes of Administration: IV (preferred), IM (with procaine to reduce pain)<br /> *Common Trade Names: Calcium Disodium Versenate, CaNa2EDTA<br /> <br /> ==Adult Dosing==<br /> ===[[Lead poisoning]] (symptomatic or BLL &gt;70 mcg/dL)===<br /> *1000-1500 mg/m²/day IV as continuous infusion or divided q6-12h<br /> *Maximum: 3 g/day (or 50 mg/kg/day if using weight-based dosing)<br /> *Duration: 5 days; may repeat after 2-4 day drug-free interval if needed<br /> *For [[lead encephalopathy]]: use in combination with [[dimercaprol]] (BAL); start BAL 4 hours before CaNa2EDTA<br /> <br /> ===IM dosing (if IV not available)===<br /> *Same dose; mix with 1% procaine to reduce injection pain<br /> <br /> ==Pediatric Dosing==<br /> ===[[Lead poisoning]] (BLL ≥45 mcg/dL or symptomatic)===<br /> *1000-1500 mg/m²/day IV as continuous infusion or divided q6-12h<br /> *Maximum: 50 mg/kg/day<br /> *Duration: 5 days; may repeat after 2-4 day drug-free interval<br /> *For [[lead encephalopathy]]: always use with [[dimercaprol]] (BAL); start BAL 4 hours before CaNa2EDTA<br /> <br /> ==Special Populations==<br /> ===[[Drug pregnancy categories|Pregnancy Rating]]===<br /> *B<br /> <br /> ===Lactation risk===<br /> *Unknown; use caution<br /> <br /> ===Renal Dosing===<br /> *Adult: Contraindicated in anuria; reduce dose in renal impairment; monitor renal function closely<br /> *Pediatric: Same as adult<br /> <br /> ===Hepatic Dosing===<br /> *Adult: No specific adjustment<br /> *Pediatric: No specific adjustment<br /> <br /> ==Contraindications==<br /> *Allergy to class/drug<br /> *Anuria or severe renal disease<br /> *Hepatorenal syndrome<br /> *Active [[hepatitis]]<br /> <br /> ==Adverse Reactions==<br /> ===Serious===<br /> *Nephrotoxicity (renal tubular necrosis — dose-dependent; monitor BUN/Cr daily)<br /> *Severe hypocalcemia (if disodium EDTA used instead — ensure CALCIUM disodium EDTA is used)<br /> *Cardiac arrhythmias (from electrolyte shifts)<br /> *Bone marrow suppression<br /> <br /> ===Common===<br /> *Nausea, vomiting<br /> *Injection site pain (IM)<br /> *Fever, chills<br /> *Fatigue, malaise<br /> *Transient hypotension<br /> *Zinc depletion (with prolonged courses)<br /> <br /> ==Pharmacology==<br /> *Half-life: 20-60 minutes (IV)<br /> *Metabolism: Not metabolized<br /> *Excretion: Renal (&gt;95% excreted as chelate complex within 24 hours)<br /> <br /> ==Mechanism of Action==<br /> *Forms stable, water-soluble chelate complex with divalent and trivalent metals (especially lead)<br /> *Chelate complex is excreted renally, reducing body lead burden<br /> *Does not cross the blood-brain barrier significantly (which is why BAL is used concurrently for encephalopathy)<br /> <br /> ==Comments==<br /> *CRITICAL: Ensure CALCIUM disodium EDTA (CaNa2EDTA) is used — NOT disodium EDTA (Na2EDTA), which causes fatal hypocalcemia<br /> *For lead encephalopathy, always start [[dimercaprol]] (BAL) 4 hours before CaNa2EDTA to prevent redistribution of lead into the brain<br /> *Monitor serum BUN, creatinine, electrolytes, CBC, and urinalysis daily during treatment<br /> *Adequate hydration is essential but avoid overhydration in encephalopathic patients (risk of cerebral edema)<br /> *A &quot;provocation test&quot; (single dose followed by urine lead measurement) is no longer recommended<br /> *Consider [[succimer]] (DMSA) as oral alternative for BLL 45-69 mcg/dL without encephalopathy<br /> <br /> ==Indications by Condition==<br /> ''The following table is automatically generated from disease/condition pages across WikEM.''<br /> {{#ask:[[Has DrugName::Calcium disodium EDTA]]<br /> |?Has Indication=Indication<br /> |?Has Dose=Dose<br /> |?Has Context=Context<br /> |?Has Route=Route<br /> |?Has Population=Population<br /> |format=table<br /> |headers=plain<br /> |mainlabel=-<br /> |sort=Has Indication<br /> |limit=50<br /> }}<br /> <br /> ==See Also==<br /> *[[Lead poisoning]]<br /> *[[Succimer]]<br /> *[[Dimercaprol]]<br /> *[[Deferoxamine]]<br /> <br /> ==References==<br /> &lt;references/&gt;<br /> <br /> [[Category:Pharmacology]]</div>

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