Biliary atresia - Revision history

Ostermayer: Marked this version for translation

2026-01-06T21:19:43Z

Marked this version for translation

← Older revision		Revision as of 21:19, 6 January 2026
Line 2:		Line 2:
	<translate>		<translate>

	==Background==		==Background== <!--T:1-->

			<!--T:2-->
	[[File:Bilatresia.jpg\|thumb\|Intraoperative view of complete extrahepatic biliary atresia.]]		[[File:Bilatresia.jpg\|thumb\|Intraoperative view of complete extrahepatic biliary atresia.]]
	*Rare, but leading indication for liver transplantation in children<ref>Mieli-Vergani G1, Vergani D. Biliary atresia. Semin Immunopathol. 2009 Sep;31(3):371-81. PMID: 19533128</ref>		*Rare, but leading indication for liver transplantation in children<ref>Mieli-Vergani G1, Vergani D. Biliary atresia. Semin Immunopathol. 2009 Sep;31(3):371-81. PMID: 19533128</ref>
Line 18:		Line 19:


	==Clinical Features==		==Clinical Features== <!--T:3-->

			<!--T:4-->
	*Presentation often subtle		*Presentation often subtle
	*[[Special:MyLanguage/Neonatal jaundice\|Neonatal jaundice]]		*[[Special:MyLanguage/Neonatal jaundice\|Neonatal jaundice]]
Line 29:		Line 31:


	==Differential Diagnosis==		==Differential Diagnosis== <!--T:5-->

	</translate>		</translate>
Line 37:		Line 39:


	==Evaluation==		==Evaluation== <!--T:6-->

			<!--T:7-->
	[[File:PMC3016234 247 2010 1858 Fig3 HTML.png\|thumb\|Persistent neonatal cholestasis and biopsy-proven biliary atresia in a 1.5-month-old boy. US shows the triangular cord sign (arrow in a) and increased diameter of the hepatic artery (27 mm, arrow in b)]]		[[File:PMC3016234 247 2010 1858 Fig3 HTML.png\|thumb\|Persistent neonatal cholestasis and biopsy-proven biliary atresia in a 1.5-month-old boy. US shows the triangular cord sign (arrow in a) and increased diameter of the hepatic artery (27 mm, arrow in b)]]
	*Evaluate for other causes of [[Special:MyLanguage/neonatal jaundice\|neonatal jaundice]], [[Special:MyLanguage/liver failure\|liver failure]]		*Evaluate for other causes of [[Special:MyLanguage/neonatal jaundice\|neonatal jaundice]], [[Special:MyLanguage/liver failure\|liver failure]]
Line 46:		Line 49:


	==Management==		==Management== <!--T:8-->

			<!--T:9-->
	*Surgery		*Surgery
	**Kasai procedure or [[Special:MyLanguage/liver transplant\|liver transplant]] for those who fail kasai		**Kasai procedure or [[Special:MyLanguage/liver transplant\|liver transplant]] for those who fail kasai
Line 53:		Line 57:


	==Disposition==		==Disposition== <!--T:10-->

			<!--T:11-->
	*Admit		*Admit


	==See Also==		==See Also== <!--T:12-->

			<!--T:13-->
	*[[Special:MyLanguage/Neonatal jaundice\|Neonatal jaundice]]		*[[Special:MyLanguage/Neonatal jaundice\|Neonatal jaundice]]


	==External Links==		==External Links== <!--T:14-->


	==References==		==References== <!--T:15-->

			<!--T:16-->
	https://pedemmorsels.com/biliary-atresia/		https://pedemmorsels.com/biliary-atresia/
	<references/>		<references/>
	[[Category:Pediatrics]] [[Category:GI]] [[Category:Surgery]]		[[Category:Pediatrics]] [[Category:GI]] [[Category:Surgery]]
	</translate>		</translate>

Ostermayer: Prepared the page for translation

2026-01-04T21:44:02Z

Prepared the page for translation

← Older revision		Revision as of 21:44, 4 January 2026
Line 1:		Line 1:
			<languages/>
			<translate>

	==Background==		==Background==

	[[File:Bilatresia.jpg\|thumb\|Intraoperative view of complete extrahepatic biliary atresia.]]		[[File:Bilatresia.jpg\|thumb\|Intraoperative view of complete extrahepatic biliary atresia.]]
	*Rare, but leading indication for liver transplantation in children<ref>Mieli-Vergani G1, Vergani D. Biliary atresia. Semin Immunopathol. 2009 Sep;31(3):371-81. PMID: 19533128</ref>		*Rare, but leading indication for liver transplantation in children<ref>Mieli-Vergani G1, Vergani D. Biliary atresia. Semin Immunopathol. 2009 Sep;31(3):371-81. PMID: 19533128</ref>
Line 7:		Line 11:
	**Peri/postnatal (90% of cases), possibly related to infection		**Peri/postnatal (90% of cases), possibly related to infection
	**Fetal/embryonic (10%)		**Fetal/embryonic (10%)
	***Often with other associated malformations (e.g [[congenital heart disease]], polysplenia or [[asplenic\|asplenia]], malrotation, situs inversus, portal vein or hepatic artery malformations)		***Often with other associated malformations (e.g [[Special:MyLanguage/congenital heart disease\|congenital heart disease]], polysplenia or [[Special:MyLanguage/asplenic\|asplenia]], malrotation, situs inversus, portal vein or hepatic artery malformations)

			</translate>
	{{Gallbladder disease types}}		{{Gallbladder disease types}}
			<translate>


	==Clinical Features==		==Clinical Features==

	*Presentation often subtle		*Presentation often subtle
	*[[Neonatal jaundice]]		*[[Special:MyLanguage/Neonatal jaundice\|Neonatal jaundice]]
	**High index of suspicion for jaundice that persists beyond 1st week of life or includes conjugated [[hyperbilirubinemia]]		**High index of suspicion for jaundice that persists beyond 1st week of life or includes conjugated [[Special:MyLanguage/hyperbilirubinemia\|hyperbilirubinemia]]
	*[[Hepatomegaly]]		*[[Special:MyLanguage/Hepatomegaly\|Hepatomegaly]]
	*Acholic stools		*Acholic stools
	*Dark urine		*Dark urine
	*Late findings: [[failure to thrive (peds)\|failure to thrive]], [[ascites]], splenomegaly		*Late findings: [[Special:MyLanguage/failure to thrive (peds)\|failure to thrive]], [[Special:MyLanguage/ascites\|ascites]], splenomegaly


	==Differential Diagnosis==		==Differential Diagnosis==

			</translate>
	{{Neonatal jaundice differential diagnosis}}		{{Neonatal jaundice differential diagnosis}}
			<translate>



	==Evaluation==		==Evaluation==

	[[File:PMC3016234 247 2010 1858 Fig3 HTML.png\|thumb\|Persistent neonatal cholestasis and biopsy-proven biliary atresia in a 1.5-month-old boy. US shows the triangular cord sign (arrow in a) and increased diameter of the hepatic artery (27 mm, arrow in b)]]		[[File:PMC3016234 247 2010 1858 Fig3 HTML.png\|thumb\|Persistent neonatal cholestasis and biopsy-proven biliary atresia in a 1.5-month-old boy. US shows the triangular cord sign (arrow in a) and increased diameter of the hepatic artery (27 mm, arrow in b)]]
	*Evaluate for other causes of [[neonatal jaundice]], [[liver failure]]		*Evaluate for other causes of [[Special:MyLanguage/neonatal jaundice\|neonatal jaundice]], [[Special:MyLanguage/liver failure\|liver failure]]
	*Assess for complications of liver disease (e.g. [[coagulopathy]])		*Assess for complications of liver disease (e.g. [[Special:MyLanguage/coagulopathy\|coagulopathy]])
	*[[RUQ US]] to screen for other abnormalities (though cannot definitively diagnose biliary atresia<ref>https://www.niddk.nih.gov/health-information/liver-disease/biliary-atresia/diagnosis</ref>)		*[[Special:MyLanguage/RUQ US\|RUQ US]] to screen for other abnormalities (though cannot definitively diagnose biliary atresia<ref>https://www.niddk.nih.gov/health-information/liver-disease/biliary-atresia/diagnosis</ref>)
	*Definitive diagnosis made by biopsy or surgical pathology		*Definitive diagnosis made by biopsy or surgical pathology


	==Management==		==Management==

	*Surgery		*Surgery
	**Kasai procedure or [[liver transplant]] for those who fail kasai		**Kasai procedure or [[Special:MyLanguage/liver transplant\|liver transplant]] for those who fail kasai
	*[[Coagulopathy]] (if present) responds to [[vitamin K]] supplementation		*[[Special:MyLanguage/Coagulopathy\|Coagulopathy]] (if present) responds to [[Special:MyLanguage/vitamin K\|vitamin K]] supplementation


	==Disposition==		==Disposition==

	*Admit		*Admit


	==See Also==		==See Also==
	*[[Neonatal jaundice]]
			*[[Special:MyLanguage/Neonatal jaundice\|Neonatal jaundice]]


	==External Links==		==External Links==
Line 46:		Line 67:

	==References==		==References==

	https://pedemmorsels.com/biliary-atresia/		https://pedemmorsels.com/biliary-atresia/
	<references/>		<references/>
	[[Category:Pediatrics]] [[Category:GI]] [[Category:Surgery]]		[[Category:Pediatrics]] [[Category:GI]] [[Category:Surgery]]
			</translate>

Rossdonaldson1: /* Background */

2024-02-28T22:47:03Z

Background

← Older revision		Revision as of 22:47, 28 February 2024
Line 8:		Line 8:
	**Fetal/embryonic (10%)		**Fetal/embryonic (10%)
	***Often with other associated malformations (e.g [[congenital heart disease]], polysplenia or [[asplenic\|asplenia]], malrotation, situs inversus, portal vein or hepatic artery malformations)		***Often with other associated malformations (e.g [[congenital heart disease]], polysplenia or [[asplenic\|asplenia]], malrotation, situs inversus, portal vein or hepatic artery malformations)

			{{Gallbladder disease types}}

	==Clinical Features==		==Clinical Features==

Rossdonaldson1: /* Evaluation */

2022-01-08T05:16:12Z

Evaluation

← Older revision		Revision as of 05:16, 8 January 2022
Line 23:		Line 23:

	==Evaluation==		==Evaluation==
			[[File:PMC3016234 247 2010 1858 Fig3 HTML.png\|thumb\|Persistent neonatal cholestasis and biopsy-proven biliary atresia in a 1.5-month-old boy. US shows the triangular cord sign (arrow in a) and increased diameter of the hepatic artery (27 mm, arrow in b)]]
	*Evaluate for other causes of [[neonatal jaundice]], [[liver failure]]		*Evaluate for other causes of [[neonatal jaundice]], [[liver failure]]
	*Assess for complications of liver disease (e.g. [[coagulopathy]])		*Assess for complications of liver disease (e.g. [[coagulopathy]])

Rossdonaldson1: /* Background */

2022-01-08T05:14:30Z

Background

← Older revision		Revision as of 05:14, 8 January 2022
Line 1:		Line 1:
	==Background==		==Background==
			[[File:Bilatresia.jpg\|thumb\|Intraoperative view of complete extrahepatic biliary atresia.]]
	*Rare, but leading indication for liver transplantation in children<ref>Mieli-Vergani G1, Vergani D. Biliary atresia. Semin Immunopathol. 2009 Sep;31(3):371-81. PMID: 19533128</ref>		*Rare, but leading indication for liver transplantation in children<ref>Mieli-Vergani G1, Vergani D. Biliary atresia. Semin Immunopathol. 2009 Sep;31(3):371-81. PMID: 19533128</ref>
	*Exact etiology unclear, but inflammation leads to destruction of intra/extrahepatic bile ducts		*Exact etiology unclear, but inflammation leads to destruction of intra/extrahepatic bile ducts

ClaireLewis: /* Background */

2019-09-30T23:53:52Z

Background

← Older revision		Revision as of 23:53, 30 September 2019
Line 6:		Line 6:
	**Peri/postnatal (90% of cases), possibly related to infection		**Peri/postnatal (90% of cases), possibly related to infection
	**Fetal/embryonic (10%)		**Fetal/embryonic (10%)
	***Often with other associated malformations (e.g [[congenital heart disease]], polysplenia or asplenia, malrotation, situs inversus, portal vein or hepatic artery malformations)		***Often with other associated malformations (e.g [[congenital heart disease]], polysplenia or [[asplenic\|asplenia]], malrotation, situs inversus, portal vein or hepatic artery malformations)

	==Clinical Features==		==Clinical Features==

ClaireLewis: /* Management */

2019-09-14T18:11:31Z

Management

← Older revision		Revision as of 18:11, 14 September 2019
Line 30:		Line 30:
	*Surgery		*Surgery
	**Kasai procedure or [[liver transplant]] for those who fail kasai		**Kasai procedure or [[liver transplant]] for those who fail kasai
	*[[Coagulopathy]] (if present) responds to [[vitamin K ~~supplementation~~]]		*[[Coagulopathy]] (if present) responds to [[vitamin K]] supplementation

	==Disposition==		==Disposition==

ClaireLewis at 22:09, 21 August 2019

2019-08-21T22:09:01Z

← Older revision		Revision as of 22:09, 21 August 2019
Line 44:		Line 44:
	https://pedemmorsels.com/biliary-atresia/		https://pedemmorsels.com/biliary-atresia/
	<references/>		<references/>
	[[Category:Pediatrics]] [[Category:GI]]		[[Category:Pediatrics]] [[Category:GI]] [[Category:Surgery]]

ClaireLewis: /* References */

2019-08-21T20:56:27Z

References

← Older revision		Revision as of 20:56, 21 August 2019
Line 42:		Line 42:

	==References==		==References==
			https://pedemmorsels.com/biliary-atresia/
	<references/>		<references/>
	[[Category:Pediatrics]] [[Category:GI]]		[[Category:Pediatrics]] [[Category:GI]]

ClaireLewis: Created page with "==Background== *Rare, but leading indication for liver transplantation in childrenMieli-Vergani G1, Vergani D. Biliary atresia. Semin Immunopathol. 2009 Sep;31(3):371-81...."

2019-08-21T20:56:11Z

Created page with "==Background== *Rare, but leading indication for liver transplantation in children<ref>Mieli-Vergani G1, Vergani D. Biliary atresia. Semin Immunopathol. 2009 Sep;31(3):371-81...."

New page

==Background==
*Rare, but leading indication for liver transplantation in children<ref>Mieli-Vergani G1, Vergani D. Biliary atresia. Semin Immunopathol. 2009 Sep;31(3):371-81. PMID: 19533128</ref>
*Exact etiology unclear, but inflammation leads to destruction of intra/extrahepatic bile ducts
*Prognosis ''significantly'' improved by early diagnosis<ref>Wadhwani SI1, Turmelle YP, Nagy R, Lowell J, Dillon P, Shepherd RW. Prolonged neonatal jaundice and the diagnosis of biliary atresia: a single-center analysis of trends in age at diagnosis and outcomes. Pediatrics. 2008 May;121(5):e1438-40. PMID: 18443020</ref>
*Two forms:
**Peri/postnatal (90% of cases), possibly related to infection
**Fetal/embryonic (10%)
***Often with other associated malformations (e.g [[congenital heart disease]], polysplenia or asplenia, malrotation, situs inversus, portal vein or hepatic artery malformations)

==Clinical Features==
*Presentation often subtle
*[[Neonatal jaundice]]
**High index of suspicion for jaundice that persists beyond 1st week of life or includes conjugated [[hyperbilirubinemia]]
*[[Hepatomegaly]]
*Acholic stools
*Dark urine
*Late findings: [[failure to thrive (peds)|failure to thrive]], [[ascites]], splenomegaly

==Differential Diagnosis==
{{Neonatal jaundice differential diagnosis}}

==Evaluation==
*Evaluate for other causes of [[neonatal jaundice]], [[liver failure]]
*Assess for complications of liver disease (e.g. [[coagulopathy]])
*[[RUQ US]] to screen for other abnormalities (though cannot definitively diagnose biliary atresia<ref>https://www.niddk.nih.gov/health-information/liver-disease/biliary-atresia/diagnosis</ref>)
*Definitive diagnosis made by biopsy or surgical pathology

==Management==
*Surgery
**Kasai procedure or [[liver transplant]] for those who fail kasai
*[[Coagulopathy]] (if present) responds to [[vitamin K supplementation]]

==Disposition==
*Admit

==See Also==
*[[Neonatal jaundice]]

==External Links==

==References==
<references/>
[[Category:Pediatrics]] [[Category:GI]]